Cargando…

Electro-Oxidative C3-Selenylation of Pyrido[1,2-a]pyrimidin-4-ones

In this work, we achieved a C3-selenylation of pyrido[1,2-a]pyrimidin-4-ones using an electrochemically driven external oxidant-free strategy. Various structurally diverse seleno-substituted N-heterocycles were obtained in moderate to excellent yields. Through radical trapping experiments, GC-MS ana...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shi, Jianwei, Wang, Zhichuan, Teng, Xiaoxu, Zhang, Bing, Sun, Kai, Wang, Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005275/ https://www.ncbi.nlm.nih.gov/pubmed/36903450 http://dx.doi.org/10.3390/molecules28052206

Ejemplares similares

Metal free C-3 chalcogenation (sulfenylation and selenylation) of 4H-pyrido[1,2-a]pyrimidin-4-ones
por: Ghosh, Prasanjit, et al.
Publicado: (2021)

Spiro[cyclopentane-1,2′(1′H)-pyrido[2,3-d]pyrimidin]-4′(3′H)-one
por: Shi, Daxin, et al.
Publicado: (2010)

3-(2-Chloroethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
por: Jasinski, Jerry P., et al.
Publicado: (2009)

Hexafluoroisopropyl alcohol mediated synthesis of 2,3-dihydro-4H-pyrido[1,2-a]pyrimidin-4-ones
por: Alam, Mohammad A., et al.
Publicado: (2016)

6′-Bromo-1′H-spiro[cyclohexane-1,2′-pyrido[2,3-d]pyrimidin]-4′(3′H)-one
por: Yang, Liupan, et al.
Publicado: (2011)

Pyrido[2,3-d]pyrimidin-7(8H)-ones: Synthesis and Biomedical Applications
por: Jubete, Guillem, et al.
Publicado: (2019)

Pyrido[3,4-d]pyrimidin-4(3H)-one metabolism mediated by aldehyde oxidase is blocked by C2-substitution
por: Hayes, Angela, et al.
Publicado: (2016)

Recent Advances in Light-Induced Selenylation
por: Protti, Stefano, et al.
Publicado: (2022)

Medicinal chemistry perspective of pyrido[2,3-d]pyrimidines as anticancer agents
por: Kumar, Adarsh, et al.
Publicado: (2023)

CuI-catalyzed synthesis of multisubstituted pyrido[1,2-a]pyrimidin-4-ones through tandem Ullmann-type C–N cross-coupling and intramolecular amidation reaction
por: Mo, Baichuan, et al.
Publicado: (2023)

Pyrido-Fused Deazapurine Bases: Synthesis and Glycosylation of 4-Substituted 9H-Pyrido[2′,3′:4,5]- and Pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidines
por: Veselovská, Lucia, et al.
Publicado: (2020)

Photoinduced metal-free α-selenylation of ketones
por: Dalberto, Bianca T., et al.
Publicado: (2020)

Rhodium-catalyzed selenylation and sulfenylation of quinoxalinones ‘on water’
por: Lalji, Ram Sunil Kumar, et al.
Publicado: (2023)

Synthesis and In Silico Docking of New Pyrazolo[4,3-e]pyrido[1,2-a]pyrimidine-based Cytotoxic Agents
por: Horchani, Mabrouk, et al.
Publicado: (2021)

Selenylated Imidazo[1,2-a]pyridine Induces Cell Senescence and Oxidative Stress in Chronic Myeloid Leukemia Cells
por: Burkner, Gabriella Teles, et al.
Publicado: (2023)

Design and Synthesis of a Series of Pyrido[2,3-d]pyrimidine Derivatives as CCR4 Antagonists
por: Gong, Hongwei, et al.
Publicado: (2012)

Expanding the Diversity at the C-4 Position of Pyrido[2,3-d]pyrimidin-7(8H)-ones to Achieve Biological Activity against ZAP-70
por: Masip, Victor, et al.
Publicado: (2021)

Nickel-catalyzed reductive thiolation and selenylation of unactivated alkyl bromides
por: Fang, Yi, et al.
Publicado: (2018)

Regiodivergent metal-catalyzed B(4)- and C(1)-selenylation of o-carboranes
por: Lee, Kyungsup, et al.
Publicado: (2022)

Studies of Interaction Mechanism between Pyrido [3,4-d] Pyrimidine Inhibitors and Mps1
por: Xing, Cheng, et al.
Publicado: (2021)

Exploration of Pyrido[3,4-d]pyrimidines as Antagonists of the Human Chemokine Receptor CXCR2
por: Van Hoof, Max, et al.
Publicado: (2023)

Effects of Selenylation Modification on Antioxidative Activities of Schisandra chinensis Polysaccharide
por: Yue, Chanjuan, et al.
Publicado: (2015)

Effects of Selenylation Modification on Immune-Enhancing Activity of Garlic Polysaccharide
por: Qiu, Shulei, et al.
Publicado: (2014)

Catalytic Photoredox C–H Arylation of 4-Oxo-4H-pyrido[1,2-a]pyrimidine-3-diazonium Tetrafluoroborates and Related Heteroaryl Diazonium Salts
por: Antolinc, Kris, et al.
Publicado: (2023)

[CMMIM][BF(4)(–)] Ionic Liquid-Catalyzed Facile, One-Pot Synthesis of Chromeno[4,3-d]pyrido[1,2-a]pyrimidin-6-ones: Evaluation of Their Photophysical Properties and Theoretical Calculations
por: Pasuparthy, Sai Deepak, et al.
Publicado: (2022)

Aquabis(2,3-dimethyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-olato)nickel(II)
por: Zhang, Huaihong, et al.
Publicado: (2009)

Synthesis of Some Spiro Indeno[1,2-b]pyrido[2,3-d]Pyrimidine-5,3′-Indolines as New Urease Inhibitors
por: Mohammadi Ziarani, Ghodsi, et al.
Publicado: (2016)

Synthesis, Herbicidal Activity, Mode of Action, and In Silico Analysis of Novel Pyrido[2,3-d]pyrimidine Compounds
por: Min, Lijing, et al.
Publicado: (2023)

6-(2,6-Dimethylphenyl)pyrido[2,3-d]pyrimidin-7-amine
por: Nukui, Seiji, et al.
Publicado: (2009)

Synthesis of Novel Pyrido[1,2-c]pyrimidine Derivatives with 6-Fluoro-3-(4-piperidynyl)-1,2-benzisoxazole Moiety as Potential SSRI and 5-HT(1A) Receptor Ligands
por: Król, Marek, et al.
Publicado: (2021)

Selenylated Imidazo [1,2-a]pyridine Induces Apoptosis and Oxidative Stress in 2D and 3D Models of Colon Cancer Cells
por: Gomes, Giovana Bicudo, et al.
Publicado: (2023)

Crystal structure of (E)-9-(4-nitrobenzylidene)-8,9-dihydropyrido[2,3-d]pyrrolo[1,2-a]pyrimidin-5(7H)-one
por: Khodjaniyazov, Khamid U., et al.
Publicado: (2016)

Anticancer evaluation and molecular modeling of multi-targeted kinase inhibitors based pyrido[2,3-d]pyrimidine scaffold
por: Elzahabi, Heba S. A., et al.
Publicado: (2018)

Selectfluor-mediated tandem cyclization of enaminones with diselenides toward the synthesis of 3-selenylated chromones
por: Xia, Ji-Hong, et al.
Publicado: (2023)

In Vitro Immunomodulation of the Polysaccharides from Yam (Dioscorea opposita Thunb.) in Response to a Selenylation of Lower Extent
por: Guan, Qing-Yun, et al.
Publicado: (2021)

Synthesis and Neurotropic Activity of New Heterocyclic Systems: Pyridofuro[3,2-d]pyrrolo[1,2-a]pyrimidines, Pyridofuro[3,2-d]pyrido[1,2-a]pyrimidines and Pyridofuro[3′,2′:4,5]pyrimido[1,2-a]azepines
por: Sirakanyan, Samvel N., et al.
Publicado: (2021)

An efficient synthesis of new imidazo[1,2-a]pyridine-6-carbohydrazide and pyrido[1,2-a]pyrimidine-7-carbohydrazide derivatives via a five-component cascade reaction
por: Hosseini, Hajar, et al.
Publicado: (2019)

The Syntheses of Some Novel (Naphthalen-1-yl-selenyl)acetic Acid Derivatives
por: Yavuz, Serkan, et al.
Publicado: (2005)

Direct Electrooxidative Selenylation/Cyclization of Alkynes: Access to Functionalized Benzo[b]furans
por: Hasimujiang, Balati, et al.
Publicado: (2022)

Synthesis and In Vitro Inhibition Effect of New Pyrido[2,3-d]pyrimidine Derivatives on Erythrocyte Carbonic Anhydrase I and II
por: Kuday, Hilal, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_vtv6eqcqklamsbl54cfan5c4c0