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Severity of Liver Fibrosis Is Associated with the Japanese Diet Pattern and Skeletal Muscle Mass in Patients with Nonalcoholic Fatty Liver Disease

It is not fully clear as to which dietary patterns are associated with the pathogenesis of nonalcoholic fatty liver disease (NAFLD) in Asia. We conducted a cross-sectional study of 136 consecutively recruited patients with NAFLD (49% female, median age 60 years). Severity of liver fibrosis was asses...

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Autores principales: Matsumoto, Yoshinari, Fujii, Hideki, Harima, Mika, Okamura, Haruna, Yukawa-Muto, Yoshimi, Odagiri, Naoshi, Motoyama, Hiroyuki, Kotani, Kohei, Kozuka, Ritsuzo, Kawamura, Etsushi, Hagihara, Atsushi, Uchida-Kobayashi, Sawako, Enomoto, Masaru, Yasui, Yoko, Habu, Daiki, Kawada, Norifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005291/
https://www.ncbi.nlm.nih.gov/pubmed/36904174
http://dx.doi.org/10.3390/nu15051175
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author Matsumoto, Yoshinari
Fujii, Hideki
Harima, Mika
Okamura, Haruna
Yukawa-Muto, Yoshimi
Odagiri, Naoshi
Motoyama, Hiroyuki
Kotani, Kohei
Kozuka, Ritsuzo
Kawamura, Etsushi
Hagihara, Atsushi
Uchida-Kobayashi, Sawako
Enomoto, Masaru
Yasui, Yoko
Habu, Daiki
Kawada, Norifumi
author_facet Matsumoto, Yoshinari
Fujii, Hideki
Harima, Mika
Okamura, Haruna
Yukawa-Muto, Yoshimi
Odagiri, Naoshi
Motoyama, Hiroyuki
Kotani, Kohei
Kozuka, Ritsuzo
Kawamura, Etsushi
Hagihara, Atsushi
Uchida-Kobayashi, Sawako
Enomoto, Masaru
Yasui, Yoko
Habu, Daiki
Kawada, Norifumi
author_sort Matsumoto, Yoshinari
collection PubMed
description It is not fully clear as to which dietary patterns are associated with the pathogenesis of nonalcoholic fatty liver disease (NAFLD) in Asia. We conducted a cross-sectional study of 136 consecutively recruited patients with NAFLD (49% female, median age 60 years). Severity of liver fibrosis was assessed using the Agile 3+ score, a recently proposed system based on vibration-controlled transient elastography. Dietary status was assessed using the 12-component modified Japanese diet pattern index (mJDI12). Skeletal muscle mass was assessed by bioelectrical impedance. Factors associated with intermediate–high-risk Agile 3+ scores and skeletal muscle mass (75th percentile or higher) were analyzed by multivariable logistic regression. After adjustment for confounders, such as age and sex, the mJDI12 (OR: 0.77; 95% CI: 0.61, 0.99) and skeletal muscle mass (75th percentile or higher) (OR: 0.23; 95% CI: 0.07, 0.77) were significantly associated with intermediate–high-risk Agile 3+ scores. Soybeans and soybean foods were significantly associated with skeletal muscle mass (75th percentile or higher) (OR: 1.02; 95% CI: 1.00, 1.04). In conclusion, the Japanese diet pattern was associated with the severity of liver fibrosis in Japanese patients with NAFLD. Skeletal muscle mass was also associated with the severity of liver fibrosis, and intake of soybeans and soybean foods.
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spelling pubmed-100052912023-03-11 Severity of Liver Fibrosis Is Associated with the Japanese Diet Pattern and Skeletal Muscle Mass in Patients with Nonalcoholic Fatty Liver Disease Matsumoto, Yoshinari Fujii, Hideki Harima, Mika Okamura, Haruna Yukawa-Muto, Yoshimi Odagiri, Naoshi Motoyama, Hiroyuki Kotani, Kohei Kozuka, Ritsuzo Kawamura, Etsushi Hagihara, Atsushi Uchida-Kobayashi, Sawako Enomoto, Masaru Yasui, Yoko Habu, Daiki Kawada, Norifumi Nutrients Article It is not fully clear as to which dietary patterns are associated with the pathogenesis of nonalcoholic fatty liver disease (NAFLD) in Asia. We conducted a cross-sectional study of 136 consecutively recruited patients with NAFLD (49% female, median age 60 years). Severity of liver fibrosis was assessed using the Agile 3+ score, a recently proposed system based on vibration-controlled transient elastography. Dietary status was assessed using the 12-component modified Japanese diet pattern index (mJDI12). Skeletal muscle mass was assessed by bioelectrical impedance. Factors associated with intermediate–high-risk Agile 3+ scores and skeletal muscle mass (75th percentile or higher) were analyzed by multivariable logistic regression. After adjustment for confounders, such as age and sex, the mJDI12 (OR: 0.77; 95% CI: 0.61, 0.99) and skeletal muscle mass (75th percentile or higher) (OR: 0.23; 95% CI: 0.07, 0.77) were significantly associated with intermediate–high-risk Agile 3+ scores. Soybeans and soybean foods were significantly associated with skeletal muscle mass (75th percentile or higher) (OR: 1.02; 95% CI: 1.00, 1.04). In conclusion, the Japanese diet pattern was associated with the severity of liver fibrosis in Japanese patients with NAFLD. Skeletal muscle mass was also associated with the severity of liver fibrosis, and intake of soybeans and soybean foods. MDPI 2023-02-26 /pmc/articles/PMC10005291/ /pubmed/36904174 http://dx.doi.org/10.3390/nu15051175 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Matsumoto, Yoshinari
Fujii, Hideki
Harima, Mika
Okamura, Haruna
Yukawa-Muto, Yoshimi
Odagiri, Naoshi
Motoyama, Hiroyuki
Kotani, Kohei
Kozuka, Ritsuzo
Kawamura, Etsushi
Hagihara, Atsushi
Uchida-Kobayashi, Sawako
Enomoto, Masaru
Yasui, Yoko
Habu, Daiki
Kawada, Norifumi
Severity of Liver Fibrosis Is Associated with the Japanese Diet Pattern and Skeletal Muscle Mass in Patients with Nonalcoholic Fatty Liver Disease
title Severity of Liver Fibrosis Is Associated with the Japanese Diet Pattern and Skeletal Muscle Mass in Patients with Nonalcoholic Fatty Liver Disease
title_full Severity of Liver Fibrosis Is Associated with the Japanese Diet Pattern and Skeletal Muscle Mass in Patients with Nonalcoholic Fatty Liver Disease
title_fullStr Severity of Liver Fibrosis Is Associated with the Japanese Diet Pattern and Skeletal Muscle Mass in Patients with Nonalcoholic Fatty Liver Disease
title_full_unstemmed Severity of Liver Fibrosis Is Associated with the Japanese Diet Pattern and Skeletal Muscle Mass in Patients with Nonalcoholic Fatty Liver Disease
title_short Severity of Liver Fibrosis Is Associated with the Japanese Diet Pattern and Skeletal Muscle Mass in Patients with Nonalcoholic Fatty Liver Disease
title_sort severity of liver fibrosis is associated with the japanese diet pattern and skeletal muscle mass in patients with nonalcoholic fatty liver disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005291/
https://www.ncbi.nlm.nih.gov/pubmed/36904174
http://dx.doi.org/10.3390/nu15051175
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