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Red Meat Intake, Indole-3-Acetate, and Dorea longicatena Together Affect Insulin Resistance after Gastric Bypass
Roux-en-Y Gastric bypass (RYGB) promotes improvement in type 2 diabetes (T2D) shortly after surgery, with metabolic mechanisms yet to be elucidated. This study aimed to investigate the relationship between food intake, tryptophan metabolism, and gut microbiota on the glycemic control of obese T2D wo...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005351/ https://www.ncbi.nlm.nih.gov/pubmed/36904185 http://dx.doi.org/10.3390/nu15051185 |
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author | Prudêncio, Ana Paula Aguiar Fonseca, Danielle Cristina Machado, Natasha Mendonça Alves, Juliana Tepedino Martins Sala, Priscila Fernandes, Gabriel R. Torrinhas, Raquel Susana Waitzberg, Dan Linetzky |
author_facet | Prudêncio, Ana Paula Aguiar Fonseca, Danielle Cristina Machado, Natasha Mendonça Alves, Juliana Tepedino Martins Sala, Priscila Fernandes, Gabriel R. Torrinhas, Raquel Susana Waitzberg, Dan Linetzky |
author_sort | Prudêncio, Ana Paula Aguiar |
collection | PubMed |
description | Roux-en-Y Gastric bypass (RYGB) promotes improvement in type 2 diabetes (T2D) shortly after surgery, with metabolic mechanisms yet to be elucidated. This study aimed to investigate the relationship between food intake, tryptophan metabolism, and gut microbiota on the glycemic control of obese T2D women after RYGB surgery. Twenty T2D women who underwent RYGB were evaluated before and three months after surgery. Food intake data were obtained by a seven-day food record and a food frequency questionnaire. Tryptophan metabolites were determined by untargeted metabolomic analysis, and the gut microbiota was determined by 16S rRNA sequencing. The glycemic outcomes were fasting blood glucose, HbA1C, HOMA-IR, and HOMA-beta. Linear regression models were applied to assess the associations between the changes in food intake, tryptophan metabolism, and gut microbiota on glycemic control after RYGB. All variables changed after RYGB (p < 0.05), except for tryptophan intake. Jointly, the variation in red meat intake, plasma indole-3-acetate, and Dorea longicatena was associated with postoperative HOMA-IR {R(2) 0.80, R(2) adj 0.74; p < 0.01}. Red meat intake decreased three months after bariatric surgery while indole-3-acetate and Dorea longicatena increased in the same period. These combined variables were associated with better insulin resistance in T2D women after RYGB. |
format | Online Article Text |
id | pubmed-10005351 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100053512023-03-11 Red Meat Intake, Indole-3-Acetate, and Dorea longicatena Together Affect Insulin Resistance after Gastric Bypass Prudêncio, Ana Paula Aguiar Fonseca, Danielle Cristina Machado, Natasha Mendonça Alves, Juliana Tepedino Martins Sala, Priscila Fernandes, Gabriel R. Torrinhas, Raquel Susana Waitzberg, Dan Linetzky Nutrients Article Roux-en-Y Gastric bypass (RYGB) promotes improvement in type 2 diabetes (T2D) shortly after surgery, with metabolic mechanisms yet to be elucidated. This study aimed to investigate the relationship between food intake, tryptophan metabolism, and gut microbiota on the glycemic control of obese T2D women after RYGB surgery. Twenty T2D women who underwent RYGB were evaluated before and three months after surgery. Food intake data were obtained by a seven-day food record and a food frequency questionnaire. Tryptophan metabolites were determined by untargeted metabolomic analysis, and the gut microbiota was determined by 16S rRNA sequencing. The glycemic outcomes were fasting blood glucose, HbA1C, HOMA-IR, and HOMA-beta. Linear regression models were applied to assess the associations between the changes in food intake, tryptophan metabolism, and gut microbiota on glycemic control after RYGB. All variables changed after RYGB (p < 0.05), except for tryptophan intake. Jointly, the variation in red meat intake, plasma indole-3-acetate, and Dorea longicatena was associated with postoperative HOMA-IR {R(2) 0.80, R(2) adj 0.74; p < 0.01}. Red meat intake decreased three months after bariatric surgery while indole-3-acetate and Dorea longicatena increased in the same period. These combined variables were associated with better insulin resistance in T2D women after RYGB. MDPI 2023-02-27 /pmc/articles/PMC10005351/ /pubmed/36904185 http://dx.doi.org/10.3390/nu15051185 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Prudêncio, Ana Paula Aguiar Fonseca, Danielle Cristina Machado, Natasha Mendonça Alves, Juliana Tepedino Martins Sala, Priscila Fernandes, Gabriel R. Torrinhas, Raquel Susana Waitzberg, Dan Linetzky Red Meat Intake, Indole-3-Acetate, and Dorea longicatena Together Affect Insulin Resistance after Gastric Bypass |
title | Red Meat Intake, Indole-3-Acetate, and Dorea longicatena Together Affect Insulin Resistance after Gastric Bypass |
title_full | Red Meat Intake, Indole-3-Acetate, and Dorea longicatena Together Affect Insulin Resistance after Gastric Bypass |
title_fullStr | Red Meat Intake, Indole-3-Acetate, and Dorea longicatena Together Affect Insulin Resistance after Gastric Bypass |
title_full_unstemmed | Red Meat Intake, Indole-3-Acetate, and Dorea longicatena Together Affect Insulin Resistance after Gastric Bypass |
title_short | Red Meat Intake, Indole-3-Acetate, and Dorea longicatena Together Affect Insulin Resistance after Gastric Bypass |
title_sort | red meat intake, indole-3-acetate, and dorea longicatena together affect insulin resistance after gastric bypass |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005351/ https://www.ncbi.nlm.nih.gov/pubmed/36904185 http://dx.doi.org/10.3390/nu15051185 |
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