Cargando…
Developmental Programming-Aging Interactions Have Sex-Specific and Developmental Stage of Exposure Outcomes on Life Course Circulating Corticosterone and Dehydroepiandrosterone (DHEA) Concentrations in Rats Exposed to Maternal Protein-Restricted Diets
The steroids corticosterone and dehydroepiandrosterone (DHEA) perform multiple life course functions. Rodent life-course circulating corticosterone and DHEA trajectories are unknown. We studied life course basal corticosterone and DHEA in offspring of rats fed protein-restricted (10% protein, R) or...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005360/ https://www.ncbi.nlm.nih.gov/pubmed/36904238 http://dx.doi.org/10.3390/nu15051239 |
_version_ | 1784905060910628864 |
---|---|
author | Zambrano, Elena Reyes-Castro, Luis A. Rodríguez-González, Guadalupe L. Chavira, Roberto Lomas-Soria, Consuelo Gerow, Kenneth G. Nathanielsz, Peter W. |
author_facet | Zambrano, Elena Reyes-Castro, Luis A. Rodríguez-González, Guadalupe L. Chavira, Roberto Lomas-Soria, Consuelo Gerow, Kenneth G. Nathanielsz, Peter W. |
author_sort | Zambrano, Elena |
collection | PubMed |
description | The steroids corticosterone and dehydroepiandrosterone (DHEA) perform multiple life course functions. Rodent life-course circulating corticosterone and DHEA trajectories are unknown. We studied life course basal corticosterone and DHEA in offspring of rats fed protein-restricted (10% protein, R) or control (20% protein, C), pregnancy diet first letter, and/or lactation second letter, producing four offspring groups—CC, RR, CR, and RC. We hypothesize that 1. maternal diet programs are sexually dimorphic, offspring life course steroid concentrations, and 2. an aging-related steroid will fall. Both changes differ with the plastic developmental period offspring experienced R, fetal life or postnatally, pre-weaning. Corticosterone was measured by radioimmunoassay and DHEA by ELISA. Steroid trajectories were evaluated by quadratic analysis. Female corticosterone was higher than male in all groups. Male and female corticosterone were highest in RR, peaked at 450 days, and fell thereafter. DHEA declined with aging in all-male groups. DHEA: corticosterone fell in three male groups but increased in all-female groups with age. In conclusion, life course and sexually dimorphic steroid developmental programming-aging interactions may explain differences in steroid studies at different life stages and between colonies experiencing different early-life programming. These data support our hypotheses of sex and programming influences and aging-related fall in rat life course serum steroids. Life course studies should address developmental programming-aging interactions. |
format | Online Article Text |
id | pubmed-10005360 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100053602023-03-11 Developmental Programming-Aging Interactions Have Sex-Specific and Developmental Stage of Exposure Outcomes on Life Course Circulating Corticosterone and Dehydroepiandrosterone (DHEA) Concentrations in Rats Exposed to Maternal Protein-Restricted Diets Zambrano, Elena Reyes-Castro, Luis A. Rodríguez-González, Guadalupe L. Chavira, Roberto Lomas-Soria, Consuelo Gerow, Kenneth G. Nathanielsz, Peter W. Nutrients Article The steroids corticosterone and dehydroepiandrosterone (DHEA) perform multiple life course functions. Rodent life-course circulating corticosterone and DHEA trajectories are unknown. We studied life course basal corticosterone and DHEA in offspring of rats fed protein-restricted (10% protein, R) or control (20% protein, C), pregnancy diet first letter, and/or lactation second letter, producing four offspring groups—CC, RR, CR, and RC. We hypothesize that 1. maternal diet programs are sexually dimorphic, offspring life course steroid concentrations, and 2. an aging-related steroid will fall. Both changes differ with the plastic developmental period offspring experienced R, fetal life or postnatally, pre-weaning. Corticosterone was measured by radioimmunoassay and DHEA by ELISA. Steroid trajectories were evaluated by quadratic analysis. Female corticosterone was higher than male in all groups. Male and female corticosterone were highest in RR, peaked at 450 days, and fell thereafter. DHEA declined with aging in all-male groups. DHEA: corticosterone fell in three male groups but increased in all-female groups with age. In conclusion, life course and sexually dimorphic steroid developmental programming-aging interactions may explain differences in steroid studies at different life stages and between colonies experiencing different early-life programming. These data support our hypotheses of sex and programming influences and aging-related fall in rat life course serum steroids. Life course studies should address developmental programming-aging interactions. MDPI 2023-03-01 /pmc/articles/PMC10005360/ /pubmed/36904238 http://dx.doi.org/10.3390/nu15051239 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zambrano, Elena Reyes-Castro, Luis A. Rodríguez-González, Guadalupe L. Chavira, Roberto Lomas-Soria, Consuelo Gerow, Kenneth G. Nathanielsz, Peter W. Developmental Programming-Aging Interactions Have Sex-Specific and Developmental Stage of Exposure Outcomes on Life Course Circulating Corticosterone and Dehydroepiandrosterone (DHEA) Concentrations in Rats Exposed to Maternal Protein-Restricted Diets |
title | Developmental Programming-Aging Interactions Have Sex-Specific and Developmental Stage of Exposure Outcomes on Life Course Circulating Corticosterone and Dehydroepiandrosterone (DHEA) Concentrations in Rats Exposed to Maternal Protein-Restricted Diets |
title_full | Developmental Programming-Aging Interactions Have Sex-Specific and Developmental Stage of Exposure Outcomes on Life Course Circulating Corticosterone and Dehydroepiandrosterone (DHEA) Concentrations in Rats Exposed to Maternal Protein-Restricted Diets |
title_fullStr | Developmental Programming-Aging Interactions Have Sex-Specific and Developmental Stage of Exposure Outcomes on Life Course Circulating Corticosterone and Dehydroepiandrosterone (DHEA) Concentrations in Rats Exposed to Maternal Protein-Restricted Diets |
title_full_unstemmed | Developmental Programming-Aging Interactions Have Sex-Specific and Developmental Stage of Exposure Outcomes on Life Course Circulating Corticosterone and Dehydroepiandrosterone (DHEA) Concentrations in Rats Exposed to Maternal Protein-Restricted Diets |
title_short | Developmental Programming-Aging Interactions Have Sex-Specific and Developmental Stage of Exposure Outcomes on Life Course Circulating Corticosterone and Dehydroepiandrosterone (DHEA) Concentrations in Rats Exposed to Maternal Protein-Restricted Diets |
title_sort | developmental programming-aging interactions have sex-specific and developmental stage of exposure outcomes on life course circulating corticosterone and dehydroepiandrosterone (dhea) concentrations in rats exposed to maternal protein-restricted diets |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005360/ https://www.ncbi.nlm.nih.gov/pubmed/36904238 http://dx.doi.org/10.3390/nu15051239 |
work_keys_str_mv | AT zambranoelena developmentalprogrammingaginginteractionshavesexspecificanddevelopmentalstageofexposureoutcomesonlifecoursecirculatingcorticosteroneanddehydroepiandrosteronedheaconcentrationsinratsexposedtomaternalproteinrestricteddiets AT reyescastroluisa developmentalprogrammingaginginteractionshavesexspecificanddevelopmentalstageofexposureoutcomesonlifecoursecirculatingcorticosteroneanddehydroepiandrosteronedheaconcentrationsinratsexposedtomaternalproteinrestricteddiets AT rodriguezgonzalezguadalupel developmentalprogrammingaginginteractionshavesexspecificanddevelopmentalstageofexposureoutcomesonlifecoursecirculatingcorticosteroneanddehydroepiandrosteronedheaconcentrationsinratsexposedtomaternalproteinrestricteddiets AT chaviraroberto developmentalprogrammingaginginteractionshavesexspecificanddevelopmentalstageofexposureoutcomesonlifecoursecirculatingcorticosteroneanddehydroepiandrosteronedheaconcentrationsinratsexposedtomaternalproteinrestricteddiets AT lomassoriaconsuelo developmentalprogrammingaginginteractionshavesexspecificanddevelopmentalstageofexposureoutcomesonlifecoursecirculatingcorticosteroneanddehydroepiandrosteronedheaconcentrationsinratsexposedtomaternalproteinrestricteddiets AT gerowkennethg developmentalprogrammingaginginteractionshavesexspecificanddevelopmentalstageofexposureoutcomesonlifecoursecirculatingcorticosteroneanddehydroepiandrosteronedheaconcentrationsinratsexposedtomaternalproteinrestricteddiets AT nathanielszpeterw developmentalprogrammingaginginteractionshavesexspecificanddevelopmentalstageofexposureoutcomesonlifecoursecirculatingcorticosteroneanddehydroepiandrosteronedheaconcentrationsinratsexposedtomaternalproteinrestricteddiets |