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Multifunctional Fe(3)O(4) Nanoparticles Filled Polydopamine Hollow Rods for Antibacterial Biofilm Treatment

This work reports the use of mesoporous silica rods as templates for the step-wise preparation of multifunctional Fe(3)O(4) NPs filled polydopamine hollow rods (Fe(3)O(4)@PDA HR). The capacity of as-synthesized Fe(3)O(4)@PDA HR as a new drug carrier platform was assessed by its loading and the trigg...

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Autores principales: Tran, Huy Quang, Alam, Husna, Goff, Abigail, Daeneke, Torben, Bhave, Mrinal, Yu, Aimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005400/
https://www.ncbi.nlm.nih.gov/pubmed/36903577
http://dx.doi.org/10.3390/molecules28052325
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author Tran, Huy Quang
Alam, Husna
Goff, Abigail
Daeneke, Torben
Bhave, Mrinal
Yu, Aimin
author_facet Tran, Huy Quang
Alam, Husna
Goff, Abigail
Daeneke, Torben
Bhave, Mrinal
Yu, Aimin
author_sort Tran, Huy Quang
collection PubMed
description This work reports the use of mesoporous silica rods as templates for the step-wise preparation of multifunctional Fe(3)O(4) NPs filled polydopamine hollow rods (Fe(3)O(4)@PDA HR). The capacity of as-synthesized Fe(3)O(4)@PDA HR as a new drug carrier platform was assessed by its loading and the triggered release of fosfomycin under various stimulations. It was found that the release of fosfomycin was pH dependent with ~89% of fosfomycin being released in pH 5 after 24 h, which was 2-fold higher than that in pH 7. The magnetic properties of Fe(3)O(4) NPs and the photothermal properties of PDA enabled the triggered release of fosfomycin upon the exposure to rotational magnetic field, or NIR laser irradiation. Additionally, the capability of using multifunctional Fe(3)O(4)@PDA HR to eliminate preformed bacterial biofilm was demonstrated. Upon exposure to the rotational magnetic field, the biomass of a preformed biofilm was significantly reduced by 65.3% after a 20 min treatment with Fe(3)O(4)@PDA HR. Again, due to the excellent photothermal properties of PDA, a dramatic biomass decline (72.5%) was achieved after 10 min of laser exposure. This study offers an alternative approach of using drug carrier platform as a physical mean to kill pathogenic bacteria along with its traditional use for drug delivery.
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spelling pubmed-100054002023-03-11 Multifunctional Fe(3)O(4) Nanoparticles Filled Polydopamine Hollow Rods for Antibacterial Biofilm Treatment Tran, Huy Quang Alam, Husna Goff, Abigail Daeneke, Torben Bhave, Mrinal Yu, Aimin Molecules Article This work reports the use of mesoporous silica rods as templates for the step-wise preparation of multifunctional Fe(3)O(4) NPs filled polydopamine hollow rods (Fe(3)O(4)@PDA HR). The capacity of as-synthesized Fe(3)O(4)@PDA HR as a new drug carrier platform was assessed by its loading and the triggered release of fosfomycin under various stimulations. It was found that the release of fosfomycin was pH dependent with ~89% of fosfomycin being released in pH 5 after 24 h, which was 2-fold higher than that in pH 7. The magnetic properties of Fe(3)O(4) NPs and the photothermal properties of PDA enabled the triggered release of fosfomycin upon the exposure to rotational magnetic field, or NIR laser irradiation. Additionally, the capability of using multifunctional Fe(3)O(4)@PDA HR to eliminate preformed bacterial biofilm was demonstrated. Upon exposure to the rotational magnetic field, the biomass of a preformed biofilm was significantly reduced by 65.3% after a 20 min treatment with Fe(3)O(4)@PDA HR. Again, due to the excellent photothermal properties of PDA, a dramatic biomass decline (72.5%) was achieved after 10 min of laser exposure. This study offers an alternative approach of using drug carrier platform as a physical mean to kill pathogenic bacteria along with its traditional use for drug delivery. MDPI 2023-03-02 /pmc/articles/PMC10005400/ /pubmed/36903577 http://dx.doi.org/10.3390/molecules28052325 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tran, Huy Quang
Alam, Husna
Goff, Abigail
Daeneke, Torben
Bhave, Mrinal
Yu, Aimin
Multifunctional Fe(3)O(4) Nanoparticles Filled Polydopamine Hollow Rods for Antibacterial Biofilm Treatment
title Multifunctional Fe(3)O(4) Nanoparticles Filled Polydopamine Hollow Rods for Antibacterial Biofilm Treatment
title_full Multifunctional Fe(3)O(4) Nanoparticles Filled Polydopamine Hollow Rods for Antibacterial Biofilm Treatment
title_fullStr Multifunctional Fe(3)O(4) Nanoparticles Filled Polydopamine Hollow Rods for Antibacterial Biofilm Treatment
title_full_unstemmed Multifunctional Fe(3)O(4) Nanoparticles Filled Polydopamine Hollow Rods for Antibacterial Biofilm Treatment
title_short Multifunctional Fe(3)O(4) Nanoparticles Filled Polydopamine Hollow Rods for Antibacterial Biofilm Treatment
title_sort multifunctional fe(3)o(4) nanoparticles filled polydopamine hollow rods for antibacterial biofilm treatment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005400/
https://www.ncbi.nlm.nih.gov/pubmed/36903577
http://dx.doi.org/10.3390/molecules28052325
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