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Systematic Review on Individualized Versus Standardized Parenteral Nutrition in Preterm Infants

The need for high quality evidence is recognized for optimizing practices of parenteral nutrition (PN). The purpose of the present systematic review is to update the available evidence and investigate the effect of standardized PN (SPN) vs. individualized PN (IPN) on protein intake, immediate morbid...

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Autores principales: Mihatsch, Walter, Jiménez Varas, Miguel Ángel, Diehl, Lucia Lorenzino, Carnielli, Virgilio, Schuler, Rahel, Gebauer, Corinna, Sáenz de Pipaón Marcos, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005430/
https://www.ncbi.nlm.nih.gov/pubmed/36904223
http://dx.doi.org/10.3390/nu15051224
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author Mihatsch, Walter
Jiménez Varas, Miguel Ángel
Diehl, Lucia Lorenzino
Carnielli, Virgilio
Schuler, Rahel
Gebauer, Corinna
Sáenz de Pipaón Marcos, Miguel
author_facet Mihatsch, Walter
Jiménez Varas, Miguel Ángel
Diehl, Lucia Lorenzino
Carnielli, Virgilio
Schuler, Rahel
Gebauer, Corinna
Sáenz de Pipaón Marcos, Miguel
author_sort Mihatsch, Walter
collection PubMed
description The need for high quality evidence is recognized for optimizing practices of parenteral nutrition (PN). The purpose of the present systematic review is to update the available evidence and investigate the effect of standardized PN (SPN) vs. individualized PN (IPN) on protein intake, immediate morbidities, growth, and long-term outcome in preterm infants. A literature search was performed on articles published in the period from 1/2015 to 11/2022 in PubMed and Cochrane database for trials on parenteral nutrition in preterm infants. Three new studies were identified. All new identified trials were nonrandomized observational trials using historical controls. SPN may increase weight and occipital frontal circumference gain and lower the value of maximum weight loss. More recent trials suggest that SPN may easily increase early protein intake. SPN may reduce the sepsis incidence, but overall, no significant effect was found. There was no significant effect of standardization of PN on mortality or stage ≥2 necrotizing enterocolite (NEC) incidence. In conclusion SPN may improve growth through higher nutrient (especially protein) intake and has no effect on sepsis, NEC, mortality, or days of PN.
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spelling pubmed-100054302023-03-11 Systematic Review on Individualized Versus Standardized Parenteral Nutrition in Preterm Infants Mihatsch, Walter Jiménez Varas, Miguel Ángel Diehl, Lucia Lorenzino Carnielli, Virgilio Schuler, Rahel Gebauer, Corinna Sáenz de Pipaón Marcos, Miguel Nutrients Review The need for high quality evidence is recognized for optimizing practices of parenteral nutrition (PN). The purpose of the present systematic review is to update the available evidence and investigate the effect of standardized PN (SPN) vs. individualized PN (IPN) on protein intake, immediate morbidities, growth, and long-term outcome in preterm infants. A literature search was performed on articles published in the period from 1/2015 to 11/2022 in PubMed and Cochrane database for trials on parenteral nutrition in preterm infants. Three new studies were identified. All new identified trials were nonrandomized observational trials using historical controls. SPN may increase weight and occipital frontal circumference gain and lower the value of maximum weight loss. More recent trials suggest that SPN may easily increase early protein intake. SPN may reduce the sepsis incidence, but overall, no significant effect was found. There was no significant effect of standardization of PN on mortality or stage ≥2 necrotizing enterocolite (NEC) incidence. In conclusion SPN may improve growth through higher nutrient (especially protein) intake and has no effect on sepsis, NEC, mortality, or days of PN. MDPI 2023-02-28 /pmc/articles/PMC10005430/ /pubmed/36904223 http://dx.doi.org/10.3390/nu15051224 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mihatsch, Walter
Jiménez Varas, Miguel Ángel
Diehl, Lucia Lorenzino
Carnielli, Virgilio
Schuler, Rahel
Gebauer, Corinna
Sáenz de Pipaón Marcos, Miguel
Systematic Review on Individualized Versus Standardized Parenteral Nutrition in Preterm Infants
title Systematic Review on Individualized Versus Standardized Parenteral Nutrition in Preterm Infants
title_full Systematic Review on Individualized Versus Standardized Parenteral Nutrition in Preterm Infants
title_fullStr Systematic Review on Individualized Versus Standardized Parenteral Nutrition in Preterm Infants
title_full_unstemmed Systematic Review on Individualized Versus Standardized Parenteral Nutrition in Preterm Infants
title_short Systematic Review on Individualized Versus Standardized Parenteral Nutrition in Preterm Infants
title_sort systematic review on individualized versus standardized parenteral nutrition in preterm infants
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005430/
https://www.ncbi.nlm.nih.gov/pubmed/36904223
http://dx.doi.org/10.3390/nu15051224
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