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Systematic Review on Individualized Versus Standardized Parenteral Nutrition in Preterm Infants
The need for high quality evidence is recognized for optimizing practices of parenteral nutrition (PN). The purpose of the present systematic review is to update the available evidence and investigate the effect of standardized PN (SPN) vs. individualized PN (IPN) on protein intake, immediate morbid...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005430/ https://www.ncbi.nlm.nih.gov/pubmed/36904223 http://dx.doi.org/10.3390/nu15051224 |
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author | Mihatsch, Walter Jiménez Varas, Miguel Ángel Diehl, Lucia Lorenzino Carnielli, Virgilio Schuler, Rahel Gebauer, Corinna Sáenz de Pipaón Marcos, Miguel |
author_facet | Mihatsch, Walter Jiménez Varas, Miguel Ángel Diehl, Lucia Lorenzino Carnielli, Virgilio Schuler, Rahel Gebauer, Corinna Sáenz de Pipaón Marcos, Miguel |
author_sort | Mihatsch, Walter |
collection | PubMed |
description | The need for high quality evidence is recognized for optimizing practices of parenteral nutrition (PN). The purpose of the present systematic review is to update the available evidence and investigate the effect of standardized PN (SPN) vs. individualized PN (IPN) on protein intake, immediate morbidities, growth, and long-term outcome in preterm infants. A literature search was performed on articles published in the period from 1/2015 to 11/2022 in PubMed and Cochrane database for trials on parenteral nutrition in preterm infants. Three new studies were identified. All new identified trials were nonrandomized observational trials using historical controls. SPN may increase weight and occipital frontal circumference gain and lower the value of maximum weight loss. More recent trials suggest that SPN may easily increase early protein intake. SPN may reduce the sepsis incidence, but overall, no significant effect was found. There was no significant effect of standardization of PN on mortality or stage ≥2 necrotizing enterocolite (NEC) incidence. In conclusion SPN may improve growth through higher nutrient (especially protein) intake and has no effect on sepsis, NEC, mortality, or days of PN. |
format | Online Article Text |
id | pubmed-10005430 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100054302023-03-11 Systematic Review on Individualized Versus Standardized Parenteral Nutrition in Preterm Infants Mihatsch, Walter Jiménez Varas, Miguel Ángel Diehl, Lucia Lorenzino Carnielli, Virgilio Schuler, Rahel Gebauer, Corinna Sáenz de Pipaón Marcos, Miguel Nutrients Review The need for high quality evidence is recognized for optimizing practices of parenteral nutrition (PN). The purpose of the present systematic review is to update the available evidence and investigate the effect of standardized PN (SPN) vs. individualized PN (IPN) on protein intake, immediate morbidities, growth, and long-term outcome in preterm infants. A literature search was performed on articles published in the period from 1/2015 to 11/2022 in PubMed and Cochrane database for trials on parenteral nutrition in preterm infants. Three new studies were identified. All new identified trials were nonrandomized observational trials using historical controls. SPN may increase weight and occipital frontal circumference gain and lower the value of maximum weight loss. More recent trials suggest that SPN may easily increase early protein intake. SPN may reduce the sepsis incidence, but overall, no significant effect was found. There was no significant effect of standardization of PN on mortality or stage ≥2 necrotizing enterocolite (NEC) incidence. In conclusion SPN may improve growth through higher nutrient (especially protein) intake and has no effect on sepsis, NEC, mortality, or days of PN. MDPI 2023-02-28 /pmc/articles/PMC10005430/ /pubmed/36904223 http://dx.doi.org/10.3390/nu15051224 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mihatsch, Walter Jiménez Varas, Miguel Ángel Diehl, Lucia Lorenzino Carnielli, Virgilio Schuler, Rahel Gebauer, Corinna Sáenz de Pipaón Marcos, Miguel Systematic Review on Individualized Versus Standardized Parenteral Nutrition in Preterm Infants |
title | Systematic Review on Individualized Versus Standardized Parenteral Nutrition in Preterm Infants |
title_full | Systematic Review on Individualized Versus Standardized Parenteral Nutrition in Preterm Infants |
title_fullStr | Systematic Review on Individualized Versus Standardized Parenteral Nutrition in Preterm Infants |
title_full_unstemmed | Systematic Review on Individualized Versus Standardized Parenteral Nutrition in Preterm Infants |
title_short | Systematic Review on Individualized Versus Standardized Parenteral Nutrition in Preterm Infants |
title_sort | systematic review on individualized versus standardized parenteral nutrition in preterm infants |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005430/ https://www.ncbi.nlm.nih.gov/pubmed/36904223 http://dx.doi.org/10.3390/nu15051224 |
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