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Consumption of Coffee and Tea Is Associated with Macular Retinal Nerve Fiber Layer Thickness: Results from the UK Biobank

Coffee and tea drinking are thought to be protective for the development and progression of neurodegenerative disorders. This study aims to investigate associations between coffee and tea consumption with macular retinal nerve fiber layer (mRNFL) thickness, a marker of neurodegeneration. After quali...

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Autores principales: Yuan, Yixiong, Bulloch, Gabriella, Zhang, Shiran, Chen, Yanping, Yang, Shaopeng, Wang, Wei, Zhu, Zhuoting, He, Mingguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005476/
https://www.ncbi.nlm.nih.gov/pubmed/36904194
http://dx.doi.org/10.3390/nu15051196
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author Yuan, Yixiong
Bulloch, Gabriella
Zhang, Shiran
Chen, Yanping
Yang, Shaopeng
Wang, Wei
Zhu, Zhuoting
He, Mingguang
author_facet Yuan, Yixiong
Bulloch, Gabriella
Zhang, Shiran
Chen, Yanping
Yang, Shaopeng
Wang, Wei
Zhu, Zhuoting
He, Mingguang
author_sort Yuan, Yixiong
collection PubMed
description Coffee and tea drinking are thought to be protective for the development and progression of neurodegenerative disorders. This study aims to investigate associations between coffee and tea consumption with macular retinal nerve fiber layer (mRNFL) thickness, a marker of neurodegeneration. After quality control and eligibility screening, 35,557 out of 67,321 United Kingdom (UK) Biobank participants from six assessment centers were included in this cross-sectional study. In the touchscreen questionnaire, participants were asked how many cups of coffee and tea were consumed daily on average over the last year. Self-reported coffee and tea consumption were divided into four categories including 0 cup/day, 0.5–1 cups/day, 2–3 cups/day, and ≥4 cups/day, respectively. The mRNFL thickness was measured by the optical coherence tomography (Topcon 3D OCT-1000 Mark II) and automatically analyzed by segmentation algorithms. After adjusting for covariates, coffee consumption was significantly associated with an increased mRNFL thickness (β = 0.13, 95% CI = 0.01~0.25), which was more prominent in those who drank 2~3 cups coffee per day (β = 0.16, 95% CI = 0.03~0.30). The mRNFL thickness was also significantly increased in tea drinkers (β = 0.13, 95% CI = 0.01~0.26), especially for those who drank more than 4 cups of tea per day (β = 0.15, 95% CI = 0.01~0.29). The positive associations with mRNFL thickness, indicating that both coffee and tea consumptions had likely neuroprotective potentials. Causal links and underlying mechanisms for these associations should be explored further.
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spelling pubmed-100054762023-03-11 Consumption of Coffee and Tea Is Associated with Macular Retinal Nerve Fiber Layer Thickness: Results from the UK Biobank Yuan, Yixiong Bulloch, Gabriella Zhang, Shiran Chen, Yanping Yang, Shaopeng Wang, Wei Zhu, Zhuoting He, Mingguang Nutrients Article Coffee and tea drinking are thought to be protective for the development and progression of neurodegenerative disorders. This study aims to investigate associations between coffee and tea consumption with macular retinal nerve fiber layer (mRNFL) thickness, a marker of neurodegeneration. After quality control and eligibility screening, 35,557 out of 67,321 United Kingdom (UK) Biobank participants from six assessment centers were included in this cross-sectional study. In the touchscreen questionnaire, participants were asked how many cups of coffee and tea were consumed daily on average over the last year. Self-reported coffee and tea consumption were divided into four categories including 0 cup/day, 0.5–1 cups/day, 2–3 cups/day, and ≥4 cups/day, respectively. The mRNFL thickness was measured by the optical coherence tomography (Topcon 3D OCT-1000 Mark II) and automatically analyzed by segmentation algorithms. After adjusting for covariates, coffee consumption was significantly associated with an increased mRNFL thickness (β = 0.13, 95% CI = 0.01~0.25), which was more prominent in those who drank 2~3 cups coffee per day (β = 0.16, 95% CI = 0.03~0.30). The mRNFL thickness was also significantly increased in tea drinkers (β = 0.13, 95% CI = 0.01~0.26), especially for those who drank more than 4 cups of tea per day (β = 0.15, 95% CI = 0.01~0.29). The positive associations with mRNFL thickness, indicating that both coffee and tea consumptions had likely neuroprotective potentials. Causal links and underlying mechanisms for these associations should be explored further. MDPI 2023-02-27 /pmc/articles/PMC10005476/ /pubmed/36904194 http://dx.doi.org/10.3390/nu15051196 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yuan, Yixiong
Bulloch, Gabriella
Zhang, Shiran
Chen, Yanping
Yang, Shaopeng
Wang, Wei
Zhu, Zhuoting
He, Mingguang
Consumption of Coffee and Tea Is Associated with Macular Retinal Nerve Fiber Layer Thickness: Results from the UK Biobank
title Consumption of Coffee and Tea Is Associated with Macular Retinal Nerve Fiber Layer Thickness: Results from the UK Biobank
title_full Consumption of Coffee and Tea Is Associated with Macular Retinal Nerve Fiber Layer Thickness: Results from the UK Biobank
title_fullStr Consumption of Coffee and Tea Is Associated with Macular Retinal Nerve Fiber Layer Thickness: Results from the UK Biobank
title_full_unstemmed Consumption of Coffee and Tea Is Associated with Macular Retinal Nerve Fiber Layer Thickness: Results from the UK Biobank
title_short Consumption of Coffee and Tea Is Associated with Macular Retinal Nerve Fiber Layer Thickness: Results from the UK Biobank
title_sort consumption of coffee and tea is associated with macular retinal nerve fiber layer thickness: results from the uk biobank
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005476/
https://www.ncbi.nlm.nih.gov/pubmed/36904194
http://dx.doi.org/10.3390/nu15051196
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