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The Associations between Multiple Essential Metal(loid)s and Gut Microbiota in Chinese Community-Dwelling Older Adults

Several experimental studies have suggested that individual essential metal(loid)s (EMs) could regulate the gut microbiota. However, human studies assessing the associations between EMs and gut microbiota are limited. This study aimed to examine the associations of individual and multiple EMs with t...

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Autores principales: Zhang, Jianghui, Wang, Yuan, Chen, Guimei, Wang, Hongli, Sun, Liang, Zhang, Dongmei, Tao, Fangbiao, Zhang, Zhihua, Yang, Linsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005492/
https://www.ncbi.nlm.nih.gov/pubmed/36904137
http://dx.doi.org/10.3390/nu15051137
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author Zhang, Jianghui
Wang, Yuan
Chen, Guimei
Wang, Hongli
Sun, Liang
Zhang, Dongmei
Tao, Fangbiao
Zhang, Zhihua
Yang, Linsheng
author_facet Zhang, Jianghui
Wang, Yuan
Chen, Guimei
Wang, Hongli
Sun, Liang
Zhang, Dongmei
Tao, Fangbiao
Zhang, Zhihua
Yang, Linsheng
author_sort Zhang, Jianghui
collection PubMed
description Several experimental studies have suggested that individual essential metal(loid)s (EMs) could regulate the gut microbiota. However, human studies assessing the associations between EMs and gut microbiota are limited. This study aimed to examine the associations of individual and multiple EMs with the compositions of the gut microbiota in older adults. A total of 270 Chinese community-dwelling people over 60 years old were included in this study. Urinary concentrations of selected EMs, including vanadium (V), cobalt (Co), selenium (Se), strontium (Sr), magnesium (Mg), calcium (Ca), and molybdenum (Mo), were examined by inductively coupled plasma mass spectrometry. The gut microbiome was assessed using the 16S rRNA gene sequencing analysis. The zero-inflated probabilistic principal components analysis PCA (ZIPPCA) model was performed to denoise substantial noise in microbiome data. Linear regression and the Bayesian Kernel Machine Regression (BKMR) models were utilized to determine the associations between urine EMs and gut microbiota. No significant association between urine EMs and gut microbiota was found in the total sample, whereas some significant associations were found in subgroup analyses: Co was negatively associated with the microbial Shannon (β = −0.072, p < 0.05) and the inverse-Simpson (β = −0.045, p < 0.05) indices among urban older adults; Ca (R(2) = 0.035) and Sr (R(2) = 0.023) exhibited significant associations with the altercations of beta diversity in females, while V (R(2) = 0.095) showed a significant association with altercations of beta diversity in those who often drank. Furthermore, the associations between partial EMs and specific bacterial taxa were also found: the negative and linear associations of Mo with Tenericutes, Sr with Bacteroidales, and Ca with Enterobacteriaceae and Lachnospiraceae, and a positive and linear association of Sr with Bifidobacteriales were found. Our findings suggested that EMs may play an important role in maintaining the steady status of gut microbiota. Prospective studies are needed to replicate these findings.
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spelling pubmed-100054922023-03-11 The Associations between Multiple Essential Metal(loid)s and Gut Microbiota in Chinese Community-Dwelling Older Adults Zhang, Jianghui Wang, Yuan Chen, Guimei Wang, Hongli Sun, Liang Zhang, Dongmei Tao, Fangbiao Zhang, Zhihua Yang, Linsheng Nutrients Article Several experimental studies have suggested that individual essential metal(loid)s (EMs) could regulate the gut microbiota. However, human studies assessing the associations between EMs and gut microbiota are limited. This study aimed to examine the associations of individual and multiple EMs with the compositions of the gut microbiota in older adults. A total of 270 Chinese community-dwelling people over 60 years old were included in this study. Urinary concentrations of selected EMs, including vanadium (V), cobalt (Co), selenium (Se), strontium (Sr), magnesium (Mg), calcium (Ca), and molybdenum (Mo), were examined by inductively coupled plasma mass spectrometry. The gut microbiome was assessed using the 16S rRNA gene sequencing analysis. The zero-inflated probabilistic principal components analysis PCA (ZIPPCA) model was performed to denoise substantial noise in microbiome data. Linear regression and the Bayesian Kernel Machine Regression (BKMR) models were utilized to determine the associations between urine EMs and gut microbiota. No significant association between urine EMs and gut microbiota was found in the total sample, whereas some significant associations were found in subgroup analyses: Co was negatively associated with the microbial Shannon (β = −0.072, p < 0.05) and the inverse-Simpson (β = −0.045, p < 0.05) indices among urban older adults; Ca (R(2) = 0.035) and Sr (R(2) = 0.023) exhibited significant associations with the altercations of beta diversity in females, while V (R(2) = 0.095) showed a significant association with altercations of beta diversity in those who often drank. Furthermore, the associations between partial EMs and specific bacterial taxa were also found: the negative and linear associations of Mo with Tenericutes, Sr with Bacteroidales, and Ca with Enterobacteriaceae and Lachnospiraceae, and a positive and linear association of Sr with Bifidobacteriales were found. Our findings suggested that EMs may play an important role in maintaining the steady status of gut microbiota. Prospective studies are needed to replicate these findings. MDPI 2023-02-24 /pmc/articles/PMC10005492/ /pubmed/36904137 http://dx.doi.org/10.3390/nu15051137 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Jianghui
Wang, Yuan
Chen, Guimei
Wang, Hongli
Sun, Liang
Zhang, Dongmei
Tao, Fangbiao
Zhang, Zhihua
Yang, Linsheng
The Associations between Multiple Essential Metal(loid)s and Gut Microbiota in Chinese Community-Dwelling Older Adults
title The Associations between Multiple Essential Metal(loid)s and Gut Microbiota in Chinese Community-Dwelling Older Adults
title_full The Associations between Multiple Essential Metal(loid)s and Gut Microbiota in Chinese Community-Dwelling Older Adults
title_fullStr The Associations between Multiple Essential Metal(loid)s and Gut Microbiota in Chinese Community-Dwelling Older Adults
title_full_unstemmed The Associations between Multiple Essential Metal(loid)s and Gut Microbiota in Chinese Community-Dwelling Older Adults
title_short The Associations between Multiple Essential Metal(loid)s and Gut Microbiota in Chinese Community-Dwelling Older Adults
title_sort associations between multiple essential metal(loid)s and gut microbiota in chinese community-dwelling older adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005492/
https://www.ncbi.nlm.nih.gov/pubmed/36904137
http://dx.doi.org/10.3390/nu15051137
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