The Inter-Organ Crosstalk Reveals an Inevitable Link between MAFLD and Extrahepatic Diseases

Fatty liver is known to be associated with extra-hepatic diseases including atherosclerotic cardiovascular disease and extra-hepatic cancers, which affect the prognosis and quality of life of the patients. The inter-organ crosstalk is mediated by metabolic abnormalities such as insulin resistance an...

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Autores principales: Tsutsumi, Tsubasa, Nakano, Dan, Hashida, Ryuki, Sano, Tomoya, Kawaguchi, Machiko, Amano, Keisuke, Kawaguchi, Takumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005526/
https://www.ncbi.nlm.nih.gov/pubmed/36904122
http://dx.doi.org/10.3390/nu15051123
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author Tsutsumi, Tsubasa
Nakano, Dan
Hashida, Ryuki
Sano, Tomoya
Kawaguchi, Machiko
Amano, Keisuke
Kawaguchi, Takumi
author_facet Tsutsumi, Tsubasa
Nakano, Dan
Hashida, Ryuki
Sano, Tomoya
Kawaguchi, Machiko
Amano, Keisuke
Kawaguchi, Takumi
author_sort Tsutsumi, Tsubasa
collection PubMed
description Fatty liver is known to be associated with extra-hepatic diseases including atherosclerotic cardiovascular disease and extra-hepatic cancers, which affect the prognosis and quality of life of the patients. The inter-organ crosstalk is mediated by metabolic abnormalities such as insulin resistance and visceral adiposity. Recently, metabolic dysfunction-associated fatty liver disease (MAFLD) was proposed as a new definition for fatty liver. MAFLD is characterized by the inclusion criteria of metabolic abnormality. Therefore, MAFLD is expected to identify patients at high risk of extra-hepatic complications. In this review, we focus on the relationships between MAFLD and multi-organ diseases. We also describe the pathogenic mechanisms of the inter-organ crosstalk.
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spelling pubmed-100055262023-03-11 The Inter-Organ Crosstalk Reveals an Inevitable Link between MAFLD and Extrahepatic Diseases Tsutsumi, Tsubasa Nakano, Dan Hashida, Ryuki Sano, Tomoya Kawaguchi, Machiko Amano, Keisuke Kawaguchi, Takumi Nutrients Review Fatty liver is known to be associated with extra-hepatic diseases including atherosclerotic cardiovascular disease and extra-hepatic cancers, which affect the prognosis and quality of life of the patients. The inter-organ crosstalk is mediated by metabolic abnormalities such as insulin resistance and visceral adiposity. Recently, metabolic dysfunction-associated fatty liver disease (MAFLD) was proposed as a new definition for fatty liver. MAFLD is characterized by the inclusion criteria of metabolic abnormality. Therefore, MAFLD is expected to identify patients at high risk of extra-hepatic complications. In this review, we focus on the relationships between MAFLD and multi-organ diseases. We also describe the pathogenic mechanisms of the inter-organ crosstalk. MDPI 2023-02-23 /pmc/articles/PMC10005526/ /pubmed/36904122 http://dx.doi.org/10.3390/nu15051123 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tsutsumi, Tsubasa
Nakano, Dan
Hashida, Ryuki
Sano, Tomoya
Kawaguchi, Machiko
Amano, Keisuke
Kawaguchi, Takumi
The Inter-Organ Crosstalk Reveals an Inevitable Link between MAFLD and Extrahepatic Diseases
title The Inter-Organ Crosstalk Reveals an Inevitable Link between MAFLD and Extrahepatic Diseases
title_full The Inter-Organ Crosstalk Reveals an Inevitable Link between MAFLD and Extrahepatic Diseases
title_fullStr The Inter-Organ Crosstalk Reveals an Inevitable Link between MAFLD and Extrahepatic Diseases
title_full_unstemmed The Inter-Organ Crosstalk Reveals an Inevitable Link between MAFLD and Extrahepatic Diseases
title_short The Inter-Organ Crosstalk Reveals an Inevitable Link between MAFLD and Extrahepatic Diseases
title_sort inter-organ crosstalk reveals an inevitable link between mafld and extrahepatic diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005526/
https://www.ncbi.nlm.nih.gov/pubmed/36904122
http://dx.doi.org/10.3390/nu15051123
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