Cargando…

Citrus Honey Ameliorates Liver Disease and Restores Gut Microbiota in Alcohol–Feeding Mice

Citrus honey (CH) is rich in nutrients that have a wide variety of biological functions, such as antibacterial, anti–inflammatory, and antioxidant activities, and which demonstrate therapeutic properties, such as anti–cancer and wound–healing abilities. However, the effects of CH on alcohol–related...

Descripción completa

Detalles Bibliográficos
Autores principales: Yi, Shengxiang, Zhang, Gaowei, Liu, Mingyan, Yu, Wenjie, Cheng, Guohua, Luo, Liping, Ning, Fangjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005585/
https://www.ncbi.nlm.nih.gov/pubmed/36904078
http://dx.doi.org/10.3390/nu15051078
_version_ 1784905117276831744
author Yi, Shengxiang
Zhang, Gaowei
Liu, Mingyan
Yu, Wenjie
Cheng, Guohua
Luo, Liping
Ning, Fangjian
author_facet Yi, Shengxiang
Zhang, Gaowei
Liu, Mingyan
Yu, Wenjie
Cheng, Guohua
Luo, Liping
Ning, Fangjian
author_sort Yi, Shengxiang
collection PubMed
description Citrus honey (CH) is rich in nutrients that have a wide variety of biological functions, such as antibacterial, anti–inflammatory, and antioxidant activities, and which demonstrate therapeutic properties, such as anti–cancer and wound–healing abilities. However, the effects of CH on alcohol–related liver disease (ALD) and the intestinal microbiota remain unknown. This study aimed to determine the alleviating effects of CH on ALD and its regulatory effects on the gut microbiota in mice. In total, 26 metabolites were identified and quantified in CH, and the results suggested that the primary metabolites were abscisic acid, 3,4–dimethoxycinnamic acid, rutin, and two markers of CH, hesperetin and hesperidin. CH lowered the levels of aspartate aminotransferase, glutamate aminotransferase, and alcohol–induced hepatic edema. CH could promote the proliferation of Bacteroidetes while reducing the abundance of Firmicutes. Additionally, CH also showed some inhibitory effects on the growth of Campylobacterota and Turicibacter. CH enhanced the secretion of short–chain fatty acids (SCFAs), such as acetic acid, propionic acid, butyric acid, and valeric acid. Given its alleviating functions in liver tissue damage and its regulatory effects on the gut microbiota and SCFAs, CH could be a promising candidate for the therapeutic treatment of ALD.
format Online
Article
Text
id pubmed-10005585
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100055852023-03-11 Citrus Honey Ameliorates Liver Disease and Restores Gut Microbiota in Alcohol–Feeding Mice Yi, Shengxiang Zhang, Gaowei Liu, Mingyan Yu, Wenjie Cheng, Guohua Luo, Liping Ning, Fangjian Nutrients Article Citrus honey (CH) is rich in nutrients that have a wide variety of biological functions, such as antibacterial, anti–inflammatory, and antioxidant activities, and which demonstrate therapeutic properties, such as anti–cancer and wound–healing abilities. However, the effects of CH on alcohol–related liver disease (ALD) and the intestinal microbiota remain unknown. This study aimed to determine the alleviating effects of CH on ALD and its regulatory effects on the gut microbiota in mice. In total, 26 metabolites were identified and quantified in CH, and the results suggested that the primary metabolites were abscisic acid, 3,4–dimethoxycinnamic acid, rutin, and two markers of CH, hesperetin and hesperidin. CH lowered the levels of aspartate aminotransferase, glutamate aminotransferase, and alcohol–induced hepatic edema. CH could promote the proliferation of Bacteroidetes while reducing the abundance of Firmicutes. Additionally, CH also showed some inhibitory effects on the growth of Campylobacterota and Turicibacter. CH enhanced the secretion of short–chain fatty acids (SCFAs), such as acetic acid, propionic acid, butyric acid, and valeric acid. Given its alleviating functions in liver tissue damage and its regulatory effects on the gut microbiota and SCFAs, CH could be a promising candidate for the therapeutic treatment of ALD. MDPI 2023-02-21 /pmc/articles/PMC10005585/ /pubmed/36904078 http://dx.doi.org/10.3390/nu15051078 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yi, Shengxiang
Zhang, Gaowei
Liu, Mingyan
Yu, Wenjie
Cheng, Guohua
Luo, Liping
Ning, Fangjian
Citrus Honey Ameliorates Liver Disease and Restores Gut Microbiota in Alcohol–Feeding Mice
title Citrus Honey Ameliorates Liver Disease and Restores Gut Microbiota in Alcohol–Feeding Mice
title_full Citrus Honey Ameliorates Liver Disease and Restores Gut Microbiota in Alcohol–Feeding Mice
title_fullStr Citrus Honey Ameliorates Liver Disease and Restores Gut Microbiota in Alcohol–Feeding Mice
title_full_unstemmed Citrus Honey Ameliorates Liver Disease and Restores Gut Microbiota in Alcohol–Feeding Mice
title_short Citrus Honey Ameliorates Liver Disease and Restores Gut Microbiota in Alcohol–Feeding Mice
title_sort citrus honey ameliorates liver disease and restores gut microbiota in alcohol–feeding mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005585/
https://www.ncbi.nlm.nih.gov/pubmed/36904078
http://dx.doi.org/10.3390/nu15051078
work_keys_str_mv AT yishengxiang citrushoneyamelioratesliverdiseaseandrestoresgutmicrobiotainalcoholfeedingmice
AT zhanggaowei citrushoneyamelioratesliverdiseaseandrestoresgutmicrobiotainalcoholfeedingmice
AT liumingyan citrushoneyamelioratesliverdiseaseandrestoresgutmicrobiotainalcoholfeedingmice
AT yuwenjie citrushoneyamelioratesliverdiseaseandrestoresgutmicrobiotainalcoholfeedingmice
AT chengguohua citrushoneyamelioratesliverdiseaseandrestoresgutmicrobiotainalcoholfeedingmice
AT luoliping citrushoneyamelioratesliverdiseaseandrestoresgutmicrobiotainalcoholfeedingmice
AT ningfangjian citrushoneyamelioratesliverdiseaseandrestoresgutmicrobiotainalcoholfeedingmice