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Bis(pyridine)enaminone as a Precursor for the Synthesis of Bis(azoles) and Bis(azine) Utilizing Recent Economic Green Chemistry Technology: The Q-Tube System

We reported herein efficient economic high-pressure synthesis procedures for the synthesis of bis(azoles) and bis(azines) by utilizing the bis(enaminone) intermediate. Bis(enaminone) reacted with hydrazine hydrate, hydroxylamine hydrochloride, guanidine hydrochloride, urea, thiourea, and malononitri...

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Autores principales: Al-Zaydi, Khadijah M., Saleh, Tamer S., Alqahtani, Norah F., Bagazi, Meaad S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005632/
https://www.ncbi.nlm.nih.gov/pubmed/36903598
http://dx.doi.org/10.3390/molecules28052355
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author Al-Zaydi, Khadijah M.
Saleh, Tamer S.
Alqahtani, Norah F.
Bagazi, Meaad S.
author_facet Al-Zaydi, Khadijah M.
Saleh, Tamer S.
Alqahtani, Norah F.
Bagazi, Meaad S.
author_sort Al-Zaydi, Khadijah M.
collection PubMed
description We reported herein efficient economic high-pressure synthesis procedures for the synthesis of bis(azoles) and bis(azines) by utilizing the bis(enaminone) intermediate. Bis(enaminone) reacted with hydrazine hydrate, hydroxylamine hydrochloride, guanidine hydrochloride, urea, thiourea, and malononitrile to form the desired bis azines and bis azoles. A combination of elemental analyses and spectral data was used to confirm the structures of the products. Compared with conventional heating, the high-pressure Q-Tube method promotes reactions in a short period of time and provides high yields.
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spelling pubmed-100056322023-03-11 Bis(pyridine)enaminone as a Precursor for the Synthesis of Bis(azoles) and Bis(azine) Utilizing Recent Economic Green Chemistry Technology: The Q-Tube System Al-Zaydi, Khadijah M. Saleh, Tamer S. Alqahtani, Norah F. Bagazi, Meaad S. Molecules Communication We reported herein efficient economic high-pressure synthesis procedures for the synthesis of bis(azoles) and bis(azines) by utilizing the bis(enaminone) intermediate. Bis(enaminone) reacted with hydrazine hydrate, hydroxylamine hydrochloride, guanidine hydrochloride, urea, thiourea, and malononitrile to form the desired bis azines and bis azoles. A combination of elemental analyses and spectral data was used to confirm the structures of the products. Compared with conventional heating, the high-pressure Q-Tube method promotes reactions in a short period of time and provides high yields. MDPI 2023-03-03 /pmc/articles/PMC10005632/ /pubmed/36903598 http://dx.doi.org/10.3390/molecules28052355 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Al-Zaydi, Khadijah M.
Saleh, Tamer S.
Alqahtani, Norah F.
Bagazi, Meaad S.
Bis(pyridine)enaminone as a Precursor for the Synthesis of Bis(azoles) and Bis(azine) Utilizing Recent Economic Green Chemistry Technology: The Q-Tube System
title Bis(pyridine)enaminone as a Precursor for the Synthesis of Bis(azoles) and Bis(azine) Utilizing Recent Economic Green Chemistry Technology: The Q-Tube System
title_full Bis(pyridine)enaminone as a Precursor for the Synthesis of Bis(azoles) and Bis(azine) Utilizing Recent Economic Green Chemistry Technology: The Q-Tube System
title_fullStr Bis(pyridine)enaminone as a Precursor for the Synthesis of Bis(azoles) and Bis(azine) Utilizing Recent Economic Green Chemistry Technology: The Q-Tube System
title_full_unstemmed Bis(pyridine)enaminone as a Precursor for the Synthesis of Bis(azoles) and Bis(azine) Utilizing Recent Economic Green Chemistry Technology: The Q-Tube System
title_short Bis(pyridine)enaminone as a Precursor for the Synthesis of Bis(azoles) and Bis(azine) Utilizing Recent Economic Green Chemistry Technology: The Q-Tube System
title_sort bis(pyridine)enaminone as a precursor for the synthesis of bis(azoles) and bis(azine) utilizing recent economic green chemistry technology: the q-tube system
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005632/
https://www.ncbi.nlm.nih.gov/pubmed/36903598
http://dx.doi.org/10.3390/molecules28052355
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