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Therapeutic Effects of Coumarins with Different Substitution Patterns

The use of derivatives of natural and synthetic origin has gained attention because of their therapeutic effects against human diseases. Coumarins are one of the most common organic molecules and are used in medicine for their pharmacological and biological effects, such as anti-inflammatory, antico...

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Autores principales: Flores-Morales, Virginia, Villasana-Ruíz, Ana P., Garza-Veloz, Idalia, González-Delgado, Samantha, Martinez-Fierro, Margarita L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005689/
https://www.ncbi.nlm.nih.gov/pubmed/36903660
http://dx.doi.org/10.3390/molecules28052413
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author Flores-Morales, Virginia
Villasana-Ruíz, Ana P.
Garza-Veloz, Idalia
González-Delgado, Samantha
Martinez-Fierro, Margarita L.
author_facet Flores-Morales, Virginia
Villasana-Ruíz, Ana P.
Garza-Veloz, Idalia
González-Delgado, Samantha
Martinez-Fierro, Margarita L.
author_sort Flores-Morales, Virginia
collection PubMed
description The use of derivatives of natural and synthetic origin has gained attention because of their therapeutic effects against human diseases. Coumarins are one of the most common organic molecules and are used in medicine for their pharmacological and biological effects, such as anti-inflammatory, anticoagulant, antihypertensive, anticonvulsant, antioxidant, antimicrobial, and neuroprotective, among others. In addition, coumarin derivates can modulate signaling pathways that impact several cell processes. The objective of this review is to provide a narrative overview of the use of coumarin-derived compounds as potential therapeutic agents, as it has been shown that substituents on the basic core of coumarin have therapeutic effects against several human diseases and types of cancer, including breast, lung, colorectal, liver, and kidney cancer. In published studies, molecular docking has represented a powerful tool to evaluate and explain how these compounds selectively bind to proteins involved in various cellular processes, leading to specific interactions with a beneficial impact on human health. We also included studies that evaluated molecular interactions to identify potential biological targets with beneficial effects against human diseases.
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spelling pubmed-100056892023-03-11 Therapeutic Effects of Coumarins with Different Substitution Patterns Flores-Morales, Virginia Villasana-Ruíz, Ana P. Garza-Veloz, Idalia González-Delgado, Samantha Martinez-Fierro, Margarita L. Molecules Review The use of derivatives of natural and synthetic origin has gained attention because of their therapeutic effects against human diseases. Coumarins are one of the most common organic molecules and are used in medicine for their pharmacological and biological effects, such as anti-inflammatory, anticoagulant, antihypertensive, anticonvulsant, antioxidant, antimicrobial, and neuroprotective, among others. In addition, coumarin derivates can modulate signaling pathways that impact several cell processes. The objective of this review is to provide a narrative overview of the use of coumarin-derived compounds as potential therapeutic agents, as it has been shown that substituents on the basic core of coumarin have therapeutic effects against several human diseases and types of cancer, including breast, lung, colorectal, liver, and kidney cancer. In published studies, molecular docking has represented a powerful tool to evaluate and explain how these compounds selectively bind to proteins involved in various cellular processes, leading to specific interactions with a beneficial impact on human health. We also included studies that evaluated molecular interactions to identify potential biological targets with beneficial effects against human diseases. MDPI 2023-03-06 /pmc/articles/PMC10005689/ /pubmed/36903660 http://dx.doi.org/10.3390/molecules28052413 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Flores-Morales, Virginia
Villasana-Ruíz, Ana P.
Garza-Veloz, Idalia
González-Delgado, Samantha
Martinez-Fierro, Margarita L.
Therapeutic Effects of Coumarins with Different Substitution Patterns
title Therapeutic Effects of Coumarins with Different Substitution Patterns
title_full Therapeutic Effects of Coumarins with Different Substitution Patterns
title_fullStr Therapeutic Effects of Coumarins with Different Substitution Patterns
title_full_unstemmed Therapeutic Effects of Coumarins with Different Substitution Patterns
title_short Therapeutic Effects of Coumarins with Different Substitution Patterns
title_sort therapeutic effects of coumarins with different substitution patterns
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005689/
https://www.ncbi.nlm.nih.gov/pubmed/36903660
http://dx.doi.org/10.3390/molecules28052413
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