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Prenatal Factors Associated with Maternal Cardiometabolic Risk Markers during Pregnancy: The ECLIPSES Study

To examine the associations of sociodemographic, lifestyle, and clinical factors with cardiometabolic risk and each of its components during pregnancy in a pregnant population from Catalonia (Spain). A prospective cohort study of 265 healthy pregnant women (39 ± 5 years) in the first and third-trime...

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Autores principales: Motevalizadeh, Ehsan, Díaz-López, Andrés, Martín-Luján, Francisco, Basora, Josep, Arija, Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005748/
https://www.ncbi.nlm.nih.gov/pubmed/36904135
http://dx.doi.org/10.3390/nu15051135
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author Motevalizadeh, Ehsan
Díaz-López, Andrés
Martín-Luján, Francisco
Basora, Josep
Arija, Victoria
author_facet Motevalizadeh, Ehsan
Díaz-López, Andrés
Martín-Luján, Francisco
Basora, Josep
Arija, Victoria
author_sort Motevalizadeh, Ehsan
collection PubMed
description To examine the associations of sociodemographic, lifestyle, and clinical factors with cardiometabolic risk and each of its components during pregnancy in a pregnant population from Catalonia (Spain). A prospective cohort study of 265 healthy pregnant women (39 ± 5 years) in the first and third-trimesters. Sociodemographic, obstetric, anthropometric, lifestyle and dietary variables were collected, and blood samples were taken. The following cardiometabolic risk markers were evaluated: BMI, blood pressure, glucose, insulin, HOMA-IR, triglycerides, LDL, and HDL-cholesterol. From these, a cluster cardiometabolic risk (CCR)-z score was created by summating all z-scores (except insulin and DBP) computed for each risk factor. Data were analyzed using bivariate analysis and multivariable linear regression. In the multivariable models, the first-trimester CCRs was positively associated with overweight/obesity status (β: 3.54, 95%CI: 2.73, 4.36) but inversely related to the level of education (β: −1.04, 95%CI: −1.94, 0.14) and physical activity (PA) (β: −1.21, 95%CI: −2.24, −0.17). The association between overweight/obesity and CCR (β:1.91, 95%CI: 1.01, 2.82) persisted into the third-trimester, whereas insufficient GWG (β: −1.14, 95%CI: −1.98, −0.30) and higher social class (β: −2.28, 95%CI: −3.42, −1.13) were significantly associated with a lower CCRs. Starting pregnancy with normal weight, higher socioeconomic and educational levels, being a non-smoker, non-consumer of alcohol, and PA were protective factors against cardiovascular risk during pregnancy.
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spelling pubmed-100057482023-03-11 Prenatal Factors Associated with Maternal Cardiometabolic Risk Markers during Pregnancy: The ECLIPSES Study Motevalizadeh, Ehsan Díaz-López, Andrés Martín-Luján, Francisco Basora, Josep Arija, Victoria Nutrients Article To examine the associations of sociodemographic, lifestyle, and clinical factors with cardiometabolic risk and each of its components during pregnancy in a pregnant population from Catalonia (Spain). A prospective cohort study of 265 healthy pregnant women (39 ± 5 years) in the first and third-trimesters. Sociodemographic, obstetric, anthropometric, lifestyle and dietary variables were collected, and blood samples were taken. The following cardiometabolic risk markers were evaluated: BMI, blood pressure, glucose, insulin, HOMA-IR, triglycerides, LDL, and HDL-cholesterol. From these, a cluster cardiometabolic risk (CCR)-z score was created by summating all z-scores (except insulin and DBP) computed for each risk factor. Data were analyzed using bivariate analysis and multivariable linear regression. In the multivariable models, the first-trimester CCRs was positively associated with overweight/obesity status (β: 3.54, 95%CI: 2.73, 4.36) but inversely related to the level of education (β: −1.04, 95%CI: −1.94, 0.14) and physical activity (PA) (β: −1.21, 95%CI: −2.24, −0.17). The association between overweight/obesity and CCR (β:1.91, 95%CI: 1.01, 2.82) persisted into the third-trimester, whereas insufficient GWG (β: −1.14, 95%CI: −1.98, −0.30) and higher social class (β: −2.28, 95%CI: −3.42, −1.13) were significantly associated with a lower CCRs. Starting pregnancy with normal weight, higher socioeconomic and educational levels, being a non-smoker, non-consumer of alcohol, and PA were protective factors against cardiovascular risk during pregnancy. MDPI 2023-02-23 /pmc/articles/PMC10005748/ /pubmed/36904135 http://dx.doi.org/10.3390/nu15051135 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Motevalizadeh, Ehsan
Díaz-López, Andrés
Martín-Luján, Francisco
Basora, Josep
Arija, Victoria
Prenatal Factors Associated with Maternal Cardiometabolic Risk Markers during Pregnancy: The ECLIPSES Study
title Prenatal Factors Associated with Maternal Cardiometabolic Risk Markers during Pregnancy: The ECLIPSES Study
title_full Prenatal Factors Associated with Maternal Cardiometabolic Risk Markers during Pregnancy: The ECLIPSES Study
title_fullStr Prenatal Factors Associated with Maternal Cardiometabolic Risk Markers during Pregnancy: The ECLIPSES Study
title_full_unstemmed Prenatal Factors Associated with Maternal Cardiometabolic Risk Markers during Pregnancy: The ECLIPSES Study
title_short Prenatal Factors Associated with Maternal Cardiometabolic Risk Markers during Pregnancy: The ECLIPSES Study
title_sort prenatal factors associated with maternal cardiometabolic risk markers during pregnancy: the eclipses study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005748/
https://www.ncbi.nlm.nih.gov/pubmed/36904135
http://dx.doi.org/10.3390/nu15051135
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