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The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA

Acute Promyelocytic Leukemia is caused by expression of the oncogenic Promyelocytic Leukemia (PML)–Retinoic Acid Receptor Alpha (RARA) fusion protein. Therapy with arsenic trioxide results in degradation of PML-RARA and PML and cures the disease. Modification of PML and PML-RARA with SUMO and ubiqui...

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Detalles Bibliográficos
Autores principales:	Jaffray, Ellis G., Tatham, Michael H., Mojsa, Barbara, Liczmanska, Magda, Rojas-Fernandez, Alejandro, Yin, Yili, Ball, Graeme, Hay, Ronald T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005898/ https://www.ncbi.nlm.nih.gov/pubmed/36880596 http://dx.doi.org/10.1083/jcb.202201027

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