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Neuroimaging profiling identifies distinct brain maturational subtypes of youth with mood and anxiety disorders
Mood and anxiety disorders typically begin in adolescence and have overlapping clinical features but marked inter-individual variation in clinical presentation. The use of multimodal neuroimaging data may offer novel insights into the underlying brain mechanisms. We applied Heterogeneity Through Dis...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005933/ https://www.ncbi.nlm.nih.gov/pubmed/36577839 http://dx.doi.org/10.1038/s41380-022-01925-9 |
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author | Ge, Ruiyang Sassi, Roberto Yatham, Lakshmi N. Frangou, Sophia |
author_facet | Ge, Ruiyang Sassi, Roberto Yatham, Lakshmi N. Frangou, Sophia |
author_sort | Ge, Ruiyang |
collection | PubMed |
description | Mood and anxiety disorders typically begin in adolescence and have overlapping clinical features but marked inter-individual variation in clinical presentation. The use of multimodal neuroimaging data may offer novel insights into the underlying brain mechanisms. We applied Heterogeneity Through Discriminative Analysis (HYDRA) to measures of regional brain morphometry, neurite density, and intracortical myelination to identify subtypes of youth, aged 9–10 years, with mood and anxiety disorders (N = 1931) compared to typically developing youth (N = 2823). We identified three subtypes that were robust to permutation testing and sample composition. Subtype 1 evidenced a pattern of imbalanced cortical-subcortical maturation compared to the typically developing group, with subcortical regions lagging behind prefrontal cortical thinning and myelination and greater cortical surface expansion globally. Subtype 2 displayed a pattern of delayed cortical maturation indicated by higher cortical thickness and lower cortical surface area expansion and myelination compared to the typically developing group. Subtype 3 showed evidence of atypical brain maturation involving globally lower cortical thickness and surface coupled with higher myelination and neural density. Subtype 1 had superior cognitive function in contrast to the other two subtypes that underperformed compared to the typically developing group. Higher levels of parental psychopathology, family conflict, and social adversity were common to all subtypes, with subtype 3 having the highest burden of adverse exposures. These analyses comprehensively characterize pre-adolescent mood and anxiety disorders, the biopsychosocial context in which they arise, and lay the foundation for the examination of the longitudinal evolution of the subtypes identified as the study sample transitions through adolescence. |
format | Online Article Text |
id | pubmed-10005933 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-100059332023-03-12 Neuroimaging profiling identifies distinct brain maturational subtypes of youth with mood and anxiety disorders Ge, Ruiyang Sassi, Roberto Yatham, Lakshmi N. Frangou, Sophia Mol Psychiatry Article Mood and anxiety disorders typically begin in adolescence and have overlapping clinical features but marked inter-individual variation in clinical presentation. The use of multimodal neuroimaging data may offer novel insights into the underlying brain mechanisms. We applied Heterogeneity Through Discriminative Analysis (HYDRA) to measures of regional brain morphometry, neurite density, and intracortical myelination to identify subtypes of youth, aged 9–10 years, with mood and anxiety disorders (N = 1931) compared to typically developing youth (N = 2823). We identified three subtypes that were robust to permutation testing and sample composition. Subtype 1 evidenced a pattern of imbalanced cortical-subcortical maturation compared to the typically developing group, with subcortical regions lagging behind prefrontal cortical thinning and myelination and greater cortical surface expansion globally. Subtype 2 displayed a pattern of delayed cortical maturation indicated by higher cortical thickness and lower cortical surface area expansion and myelination compared to the typically developing group. Subtype 3 showed evidence of atypical brain maturation involving globally lower cortical thickness and surface coupled with higher myelination and neural density. Subtype 1 had superior cognitive function in contrast to the other two subtypes that underperformed compared to the typically developing group. Higher levels of parental psychopathology, family conflict, and social adversity were common to all subtypes, with subtype 3 having the highest burden of adverse exposures. These analyses comprehensively characterize pre-adolescent mood and anxiety disorders, the biopsychosocial context in which they arise, and lay the foundation for the examination of the longitudinal evolution of the subtypes identified as the study sample transitions through adolescence. Nature Publishing Group UK 2022-12-28 2023 /pmc/articles/PMC10005933/ /pubmed/36577839 http://dx.doi.org/10.1038/s41380-022-01925-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Ge, Ruiyang Sassi, Roberto Yatham, Lakshmi N. Frangou, Sophia Neuroimaging profiling identifies distinct brain maturational subtypes of youth with mood and anxiety disorders |
title | Neuroimaging profiling identifies distinct brain maturational subtypes of youth with mood and anxiety disorders |
title_full | Neuroimaging profiling identifies distinct brain maturational subtypes of youth with mood and anxiety disorders |
title_fullStr | Neuroimaging profiling identifies distinct brain maturational subtypes of youth with mood and anxiety disorders |
title_full_unstemmed | Neuroimaging profiling identifies distinct brain maturational subtypes of youth with mood and anxiety disorders |
title_short | Neuroimaging profiling identifies distinct brain maturational subtypes of youth with mood and anxiety disorders |
title_sort | neuroimaging profiling identifies distinct brain maturational subtypes of youth with mood and anxiety disorders |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005933/ https://www.ncbi.nlm.nih.gov/pubmed/36577839 http://dx.doi.org/10.1038/s41380-022-01925-9 |
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