The pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive oncogenic signalling in triple-negative breast cancer

We have determined that expression of the pseudokinase NRBP1 positively associates with poor prognosis in triple negative breast cancer (TNBC) and is required for efficient migration, invasion and proliferation of TNBC cells in culture as well as growth of TNBC orthotopic xenografts and experimental...

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Detalles Bibliográficos
Autores principales: Yang, Xue, Cruz, Miguel I., Nguyen, Elizabeth V., Huang, Cheng, Schittenhelm, Ralf B., Luu, Jennii, Cowley, Karla J., Shin, Sung-Young, Nguyen, Lan K., Lim Kam Sian, Terry C. C., Clark, Kimberley C., Simpson, Kaylene J., Ma, Xiuquan, Daly, Roger J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005955/
https://www.ncbi.nlm.nih.gov/pubmed/36693952
http://dx.doi.org/10.1038/s41388-023-02594-w

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