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Hemidystonia secondary to pediatric thalamic glioblastoma: a case report

INTRODUCTION: Thalamic tumors are rare and uncommonly manifest as movement disorders, including hemidystonia. Despite this association, little is known about the evolution of hemidystonia. CASE DESCRIPTION: We report on a 11-year-old boy who complained of hypaesthesia and fine motor problems in the...

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Autores principales: Wolff Fernandes, Filipe, Saryyeva, Assel, Ertl, Philipp, Krauss, Joachim Kurt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006018/
https://www.ncbi.nlm.nih.gov/pubmed/36220936
http://dx.doi.org/10.1007/s00381-022-05698-y
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author Wolff Fernandes, Filipe
Saryyeva, Assel
Ertl, Philipp
Krauss, Joachim Kurt
author_facet Wolff Fernandes, Filipe
Saryyeva, Assel
Ertl, Philipp
Krauss, Joachim Kurt
author_sort Wolff Fernandes, Filipe
collection PubMed
description INTRODUCTION: Thalamic tumors are rare and uncommonly manifest as movement disorders, including hemidystonia. Despite this association, little is known about the evolution of hemidystonia. CASE DESCRIPTION: We report on a 11-year-old boy who complained of hypaesthesia and fine motor problems in the left hand. A magnetic resonance imaging showed a large mass in the right thalamus. Stereotactic biopsy revealed a WHO grade 4 astrocytoma, and the patient underwent normofractioned radiochemotherapy with proton-beam radiation and temozolomide. Three months later, a spastic hemiparesis developed on the left side, which progressed over months. Over the following months, the hemiparesis slowly improved, but hemidystonia in the same side developed. This was accompanied with radiological evidence of tumor regression, showing a persistent lesion in the ventral posterolateral and the intralaminar thalamus. CONCLUSION: This case illustrates the unusual and complex temporal course of appearance and disappearance of hemidystonia along with the regression and growth in glioblastoma involving the thalamus. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00381-022-05698-y.
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spelling pubmed-100060182023-03-12 Hemidystonia secondary to pediatric thalamic glioblastoma: a case report Wolff Fernandes, Filipe Saryyeva, Assel Ertl, Philipp Krauss, Joachim Kurt Childs Nerv Syst Case Report INTRODUCTION: Thalamic tumors are rare and uncommonly manifest as movement disorders, including hemidystonia. Despite this association, little is known about the evolution of hemidystonia. CASE DESCRIPTION: We report on a 11-year-old boy who complained of hypaesthesia and fine motor problems in the left hand. A magnetic resonance imaging showed a large mass in the right thalamus. Stereotactic biopsy revealed a WHO grade 4 astrocytoma, and the patient underwent normofractioned radiochemotherapy with proton-beam radiation and temozolomide. Three months later, a spastic hemiparesis developed on the left side, which progressed over months. Over the following months, the hemiparesis slowly improved, but hemidystonia in the same side developed. This was accompanied with radiological evidence of tumor regression, showing a persistent lesion in the ventral posterolateral and the intralaminar thalamus. CONCLUSION: This case illustrates the unusual and complex temporal course of appearance and disappearance of hemidystonia along with the regression and growth in glioblastoma involving the thalamus. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00381-022-05698-y. Springer Berlin Heidelberg 2022-10-12 2023 /pmc/articles/PMC10006018/ /pubmed/36220936 http://dx.doi.org/10.1007/s00381-022-05698-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Case Report
Wolff Fernandes, Filipe
Saryyeva, Assel
Ertl, Philipp
Krauss, Joachim Kurt
Hemidystonia secondary to pediatric thalamic glioblastoma: a case report
title Hemidystonia secondary to pediatric thalamic glioblastoma: a case report
title_full Hemidystonia secondary to pediatric thalamic glioblastoma: a case report
title_fullStr Hemidystonia secondary to pediatric thalamic glioblastoma: a case report
title_full_unstemmed Hemidystonia secondary to pediatric thalamic glioblastoma: a case report
title_short Hemidystonia secondary to pediatric thalamic glioblastoma: a case report
title_sort hemidystonia secondary to pediatric thalamic glioblastoma: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006018/
https://www.ncbi.nlm.nih.gov/pubmed/36220936
http://dx.doi.org/10.1007/s00381-022-05698-y
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