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In situ sequence-specific visualization of single methylated cytosine on tissue sections using ICON probe and rolling-circle amplification

Since epigenetic modifications differ from cell to cell, detecting the DNA methylation status of individual cells is requisite. Therefore, it is important to conduct “morphology-based epigenetics research”, in which the sequence-specific DNA methylation status is observed while maintaining tissue ar...

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Detalles Bibliográficos
Autores principales: Kitazawa, Sohei, Haraguchi, Ryuma, Takaoka, Yuki, Kitazawa, Riko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006048/
https://www.ncbi.nlm.nih.gov/pubmed/36418613
http://dx.doi.org/10.1007/s00418-022-02165-2