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cRel and Wnt5a/Frizzled 5 Receptor-Mediated Inflammatory Regulation Reveal Novel Neuroprotectin D1 Targets for Neuroprotection

ABSTRACT: Wnt5a triggers inflammatory responses and damage via NFkB/p65 in retinal pigment epithelial (RPE) cells undergoing uncompensated oxidative stress (UOS) and in experimental ischemic stroke. We found that Wnt5a-Clathrin-mediated uptake leads to NFkB/p65 activation and that Wnt5a is secreted...

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Detalles Bibliográficos
Autores principales:	Calandria, Jorgelina M., Do, Khanh V., Kala-Bhattacharjee, Sayantani, Obenaus, Andre, Belayev, Ludmila, Bazan, Nicolas G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006067/ https://www.ncbi.nlm.nih.gov/pubmed/35622188 http://dx.doi.org/10.1007/s10571-022-01231-6

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