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Identification, characterization and spatiotemporal expression analysis of the FKBP family genes in Locusta migratoria
FK506 binding proteins (FKBPs) are a highly-conserved group of proteins known to bind to FK506, an immunosuppressive drug. They play different physiological roles, including transcription regulation, protein folding, signal transduction and immunosuppression. A number of FKBP genes have been identif...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006077/ https://www.ncbi.nlm.nih.gov/pubmed/36899085 http://dx.doi.org/10.1038/s41598-023-30889-1 |
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author | Zhang, Neng Feng, Shiqian Tian, Ye Zhuang, Ling Cha, Gan Duan, Saiya Li, Hongmei Nong, Xiangqun Zhang, Zehua Tu, Xiongbing Wang, Guangjun |
author_facet | Zhang, Neng Feng, Shiqian Tian, Ye Zhuang, Ling Cha, Gan Duan, Saiya Li, Hongmei Nong, Xiangqun Zhang, Zehua Tu, Xiongbing Wang, Guangjun |
author_sort | Zhang, Neng |
collection | PubMed |
description | FK506 binding proteins (FKBPs) are a highly-conserved group of proteins known to bind to FK506, an immunosuppressive drug. They play different physiological roles, including transcription regulation, protein folding, signal transduction and immunosuppression. A number of FKBP genes have been identified in eukaryotes; however, very little information about these genes has been reported in Locusta migratoria. Here, we identified and characterized 10 FKBP genes from L. migratoria. Phylogenetic analysis and comparison of domain architectures indicated that the LmFKBP family can be divided into two subfamilies and five subclasses. Developmental and tissue expression pattern analysis revealed that all LmFKBPs transcripts, including LmFKBP46, LmFKBP12, LmFKBP47, LmFKBP79, LmFKBP16, LmFKBP24, LmFKBP44b, LmFKBP53, were periodically expressed during different developmental stages and mainly expressed in the fat body, hemolymph, testis, and ovary. In brief, our work depicts a outline but panoramic picture of LmFKBP family in L. migratoria, and provides a solid foundation to further investigate the molecular functions of LmFKBPs. |
format | Online Article Text |
id | pubmed-10006077 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-100060772023-03-12 Identification, characterization and spatiotemporal expression analysis of the FKBP family genes in Locusta migratoria Zhang, Neng Feng, Shiqian Tian, Ye Zhuang, Ling Cha, Gan Duan, Saiya Li, Hongmei Nong, Xiangqun Zhang, Zehua Tu, Xiongbing Wang, Guangjun Sci Rep Article FK506 binding proteins (FKBPs) are a highly-conserved group of proteins known to bind to FK506, an immunosuppressive drug. They play different physiological roles, including transcription regulation, protein folding, signal transduction and immunosuppression. A number of FKBP genes have been identified in eukaryotes; however, very little information about these genes has been reported in Locusta migratoria. Here, we identified and characterized 10 FKBP genes from L. migratoria. Phylogenetic analysis and comparison of domain architectures indicated that the LmFKBP family can be divided into two subfamilies and five subclasses. Developmental and tissue expression pattern analysis revealed that all LmFKBPs transcripts, including LmFKBP46, LmFKBP12, LmFKBP47, LmFKBP79, LmFKBP16, LmFKBP24, LmFKBP44b, LmFKBP53, were periodically expressed during different developmental stages and mainly expressed in the fat body, hemolymph, testis, and ovary. In brief, our work depicts a outline but panoramic picture of LmFKBP family in L. migratoria, and provides a solid foundation to further investigate the molecular functions of LmFKBPs. Nature Publishing Group UK 2023-03-10 /pmc/articles/PMC10006077/ /pubmed/36899085 http://dx.doi.org/10.1038/s41598-023-30889-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Zhang, Neng Feng, Shiqian Tian, Ye Zhuang, Ling Cha, Gan Duan, Saiya Li, Hongmei Nong, Xiangqun Zhang, Zehua Tu, Xiongbing Wang, Guangjun Identification, characterization and spatiotemporal expression analysis of the FKBP family genes in Locusta migratoria |
title | Identification, characterization and spatiotemporal expression analysis of the FKBP family genes in Locusta migratoria |
title_full | Identification, characterization and spatiotemporal expression analysis of the FKBP family genes in Locusta migratoria |
title_fullStr | Identification, characterization and spatiotemporal expression analysis of the FKBP family genes in Locusta migratoria |
title_full_unstemmed | Identification, characterization and spatiotemporal expression analysis of the FKBP family genes in Locusta migratoria |
title_short | Identification, characterization and spatiotemporal expression analysis of the FKBP family genes in Locusta migratoria |
title_sort | identification, characterization and spatiotemporal expression analysis of the fkbp family genes in locusta migratoria |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006077/ https://www.ncbi.nlm.nih.gov/pubmed/36899085 http://dx.doi.org/10.1038/s41598-023-30889-1 |
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