3D collagen migration patterns reveal a SMAD3-dependent and TGF-β1-independent mechanism of recruitment for tumour-associated fibroblasts in lung adenocarcinoma

BACKGROUND: The TGF-β1 transcription factor SMAD3 is epigenetically repressed in tumour-associated fibroblasts (TAFs) from lung squamous cell carcinoma (SCC) but not adenocarcinoma (ADC) patients, which elicits a compensatory increase in SMAD2 that renders SCC-TAFs less fibrotic. Here we examined th...

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Detalles Bibliográficos
Autores principales: Juste-Lanas, Yago, Díaz-Valdivia, Natalia, Llorente, Alejandro, Ikemori, Rafael, Bernardo, Alejandro, Arshakyan, Marselina, Borau, Carlos, Ramírez, Josep, Ruffinelli, José Carlos, Nadal, Ernest, Reguart, Noemí, García-Aznar, José M., Alcaraz, Jordi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006167/
https://www.ncbi.nlm.nih.gov/pubmed/36572730
http://dx.doi.org/10.1038/s41416-022-02093-x

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