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Enhanced pathogenicity and transmissibility of H9N2 avian influenza virus in mammals by hemagglutinin mutations combined with PB2-627K

H9N2 avian influenza viruses (AIVs) circulate globally in poultry and have become the dominant AIV subtype in China in recent years. Previously, we demonstrated that the H9N2 virus (A/chicken/Eastern China/SDKD1/2015) naturally harbors a mammalian-adaptive molecular factor (627K) in the PB2 protein...

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Detalles Bibliográficos
Autores principales:	Liu, Kaituo, Guo, Yaqian, Zheng, Huafen, Ji, Zhuxing, Cai, Miao, Gao, Ruyi, Zhang, Pinghu, Liu, Xiaowen, Xu, Xiulong, Wang, Xiaoquan, Liu, Xiufan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wuhan Institute of Virology, Chinese Academy of Sciences 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006187/ https://www.ncbi.nlm.nih.gov/pubmed/36103978 http://dx.doi.org/10.1016/j.virs.2022.09.006

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