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Intermediate-state-trapped mutants pinpoint G protein-coupled receptor conformational allostery

Understanding the roles of intermediate states in signaling is pivotal to unraveling the activation processes of G protein-coupled receptors (GPCRs). However, the field is still struggling to define these conformational states with sufficient resolution to study their individual functions. Here, we...

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Detalles Bibliográficos
Autores principales:	Wang, Xudong, Neale, Chris, Kim, Soo-Kyung, Goddard, William A., Ye, Libin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006191/ https://www.ncbi.nlm.nih.gov/pubmed/36899002 http://dx.doi.org/10.1038/s41467-023-36971-6

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