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Revisiting influenza A virus life cycle from a perspective of genome balance

Influenza A virus (IAV) genome comprises eight negative-sense RNA segments, of which the replication is well orchestrated and the delicate balance of multiple segments are dynamically regulated throughout IAV life cycle. However, previous studies seldom discuss these balances except for functional h...

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Autores principales: Du, Ruikun, Cui, Qinghua, Chen, Zinuo, Zhao, Xiujuan, Lin, Xiaojing, Rong, Lijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wuhan Institute of Virology, Chinese Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006207/
https://www.ncbi.nlm.nih.gov/pubmed/36309307
http://dx.doi.org/10.1016/j.virs.2022.10.005
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author Du, Ruikun
Cui, Qinghua
Chen, Zinuo
Zhao, Xiujuan
Lin, Xiaojing
Rong, Lijun
author_facet Du, Ruikun
Cui, Qinghua
Chen, Zinuo
Zhao, Xiujuan
Lin, Xiaojing
Rong, Lijun
author_sort Du, Ruikun
collection PubMed
description Influenza A virus (IAV) genome comprises eight negative-sense RNA segments, of which the replication is well orchestrated and the delicate balance of multiple segments are dynamically regulated throughout IAV life cycle. However, previous studies seldom discuss these balances except for functional hemagglutinin-neuraminidase balance that is pivotal for both virus entry and release. Therefore, we attempt to revisit IAV life cycle by highlighting the critical role of “genome balance”. Moreover, we raise a “balance regression” model of IAV evolution that the virus evolves to rebalance its genome after reassortment or interspecies transmission, and direct a “balance compensation” strategy to rectify the “genome imbalance” as a result of artificial modifications during creation of recombinant IAVs. This review not only improves our understanding of IAV life cycle, but also facilitates both basic and applied research of IAV in future.
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spelling pubmed-100062072023-03-12 Revisiting influenza A virus life cycle from a perspective of genome balance Du, Ruikun Cui, Qinghua Chen, Zinuo Zhao, Xiujuan Lin, Xiaojing Rong, Lijun Virol Sin Review Influenza A virus (IAV) genome comprises eight negative-sense RNA segments, of which the replication is well orchestrated and the delicate balance of multiple segments are dynamically regulated throughout IAV life cycle. However, previous studies seldom discuss these balances except for functional hemagglutinin-neuraminidase balance that is pivotal for both virus entry and release. Therefore, we attempt to revisit IAV life cycle by highlighting the critical role of “genome balance”. Moreover, we raise a “balance regression” model of IAV evolution that the virus evolves to rebalance its genome after reassortment or interspecies transmission, and direct a “balance compensation” strategy to rectify the “genome imbalance” as a result of artificial modifications during creation of recombinant IAVs. This review not only improves our understanding of IAV life cycle, but also facilitates both basic and applied research of IAV in future. Wuhan Institute of Virology, Chinese Academy of Sciences 2022-10-27 /pmc/articles/PMC10006207/ /pubmed/36309307 http://dx.doi.org/10.1016/j.virs.2022.10.005 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Du, Ruikun
Cui, Qinghua
Chen, Zinuo
Zhao, Xiujuan
Lin, Xiaojing
Rong, Lijun
Revisiting influenza A virus life cycle from a perspective of genome balance
title Revisiting influenza A virus life cycle from a perspective of genome balance
title_full Revisiting influenza A virus life cycle from a perspective of genome balance
title_fullStr Revisiting influenza A virus life cycle from a perspective of genome balance
title_full_unstemmed Revisiting influenza A virus life cycle from a perspective of genome balance
title_short Revisiting influenza A virus life cycle from a perspective of genome balance
title_sort revisiting influenza a virus life cycle from a perspective of genome balance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006207/
https://www.ncbi.nlm.nih.gov/pubmed/36309307
http://dx.doi.org/10.1016/j.virs.2022.10.005
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