Setd2 inactivation sensitizes lung adenocarcinoma to inhibitors of oxidative respiration and mTORC1 signaling

SETD2 is a tumor suppressor that is frequently inactivated in several cancer types. The mechanisms through which SETD2 inactivation promotes cancer are unclear, and whether targetable vulnerabilities exist in these tumors is unknown. Here we identify heightened mTORC1-associated gene expression prog...

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Detalles Bibliográficos
Autores principales: Walter, David M., Gladstein, Amy C., Doerig, Katherine R., Natesan, Ramakrishnan, Baskaran, Saravana G., Gudiel, A. Andrea, Adler, Keren M., Acosta, Jonuelle O., Wallace, Douglas C., Asangani, Irfan A., Feldser, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006211/
https://www.ncbi.nlm.nih.gov/pubmed/36899051
http://dx.doi.org/10.1038/s42003-023-04618-3

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