Somatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens

BACKGROUND: Identifying biomarkers to predict immune checkpoint inhibitor (ICI) efficacy is warranted. Considering that somatic mutation-derived neoantigens induce strong immune responses, patients with a high tumour mutational burden reportedly tend to respond to ICIs. However, there are several co...

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Detalles Bibliográficos
Autores principales: Ishino, Takamasa, Kawashima, Shusuke, Tanji, Etsuko, Ueno, Toshihide, Ueda, Youki, Ogasawara, Sadahisa, Sato, Kazuhito, Mano, Hiroyuki, Ishihara, Soichiro, Kato, Naoya, Kawazu, Masahito, Togashi, Yosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006227/
https://www.ncbi.nlm.nih.gov/pubmed/36732592
http://dx.doi.org/10.1038/s41416-023-02165-6

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