LYN kinase programs stromal fibroblasts to facilitate leukemic survival via regulation of c-JUN and THBS1

Microenvironmental bystander cells are essential for the progression of chronic lymphocytic leukemia (CLL). We have discovered previously that LYN kinase promotes the formation of a microenvironmental niche for CLL. Here we provide mechanistic evidence that LYN regulates the polarization of stromal...

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Detalles Bibliográficos
Autores principales: vom Stein, Alexander F., Rebollido-Rios, Rocio, Lukas, Anna, Koch, Maximilian, von Lom, Anton, Reinartz, Sebastian, Bachurski, Daniel, Rose, France, Bozek, Katarzyna, Abdallah, Ali T., Kohlhas, Viktoria, Saggau, Julia, Zölzer, Rebekka, Zhao, Yue, Bruns, Christiane, Bröckelmann, Paul J., Lohneis, Philipp, Büttner, Reinhard, Häupl, Björn, Oellerich, Thomas, Nguyen, Phuong-Hien, Hallek, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006233/
https://www.ncbi.nlm.nih.gov/pubmed/36899005
http://dx.doi.org/10.1038/s41467-023-36824-2

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