Cargando…

Phase-type models for competing risks, with emphasis on identifiability issues

We first review some main results for phase-type distributions, including a discussion of Coxian distributions and their canonical representations. We then consider the extension of phase-type modeling to cover competing risks. This extension involves the consideration of finite state Markov chains...

Descripción completa

Detalles Bibliográficos
Autor principal: Lindqvist, Bo Henry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006281/
https://www.ncbi.nlm.nih.gov/pubmed/35132532
http://dx.doi.org/10.1007/s10985-022-09547-7
_version_ 1784905278987173888
author Lindqvist, Bo Henry
author_facet Lindqvist, Bo Henry
author_sort Lindqvist, Bo Henry
collection PubMed
description We first review some main results for phase-type distributions, including a discussion of Coxian distributions and their canonical representations. We then consider the extension of phase-type modeling to cover competing risks. This extension involves the consideration of finite state Markov chains with more than one absorbing state, letting each absorbing state correspond to a particular risk. The non-uniqueness of Markov chain representations of phase-type distributions is well known. In the paper we study corresponding issues for the competing risks case with the aim of obtaining identifiable parameterizations. Statistical inference for the Coxian competing risks model is briefly discussed and some real data are analyzed for illustration.
format Online
Article
Text
id pubmed-10006281
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-100062812023-03-12 Phase-type models for competing risks, with emphasis on identifiability issues Lindqvist, Bo Henry Lifetime Data Anal Article We first review some main results for phase-type distributions, including a discussion of Coxian distributions and their canonical representations. We then consider the extension of phase-type modeling to cover competing risks. This extension involves the consideration of finite state Markov chains with more than one absorbing state, letting each absorbing state correspond to a particular risk. The non-uniqueness of Markov chain representations of phase-type distributions is well known. In the paper we study corresponding issues for the competing risks case with the aim of obtaining identifiable parameterizations. Statistical inference for the Coxian competing risks model is briefly discussed and some real data are analyzed for illustration. Springer US 2022-02-08 2023 /pmc/articles/PMC10006281/ /pubmed/35132532 http://dx.doi.org/10.1007/s10985-022-09547-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Lindqvist, Bo Henry
Phase-type models for competing risks, with emphasis on identifiability issues
title Phase-type models for competing risks, with emphasis on identifiability issues
title_full Phase-type models for competing risks, with emphasis on identifiability issues
title_fullStr Phase-type models for competing risks, with emphasis on identifiability issues
title_full_unstemmed Phase-type models for competing risks, with emphasis on identifiability issues
title_short Phase-type models for competing risks, with emphasis on identifiability issues
title_sort phase-type models for competing risks, with emphasis on identifiability issues
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006281/
https://www.ncbi.nlm.nih.gov/pubmed/35132532
http://dx.doi.org/10.1007/s10985-022-09547-7
work_keys_str_mv AT lindqvistbohenry phasetypemodelsforcompetingriskswithemphasisonidentifiabilityissues