Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is an age-related, chronic, irreversible fibrotic lung disease. IPF is associated with increased senescent cells burden, which may be alleviated with administration of senescent cell targeting drugs termed ‘senolytics’. We previously conducted an open-...

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Detalles Bibliográficos
Autores principales: Nambiar, Anoop, Kellogg, Dean, Justice, Jaime, Goros, Martin, Gelfond, Jonathan, Pascual, Rodolfo, Hashmi, Shahrukh, Masternak, Michal, Prata, Larissa, LeBrasseur, Nathan, Limper, Andrew, Kritchevsky, Stephen, Musi, Nicolas, Tchkonia, Tamara, Kirkland, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006434/
https://www.ncbi.nlm.nih.gov/pubmed/36857968
http://dx.doi.org/10.1016/j.ebiom.2023.104481

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