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Preventive or promotive effects of PRNP polymorphic heterozygosity on the onset of prion disease

The polymorphic heterozygosity of PRNP at codon 129 or 219 prevents the onset of sporadic Creutzfeldt-Jakob disease (sCJD). We investigated the association between polymorphic genotypes at codon 129 or 219 and comprehensive prion disease onset using non-CJD as a reference. EK heterozygotes at codon...

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Detalles Bibliográficos
Autores principales:	Kai, Hideaki, Teruya, Kenta, Takeuchi, Atsuko, Nakamura, Yoshikazu, Mizusawa, Hidehiro, Yamada, Masahito, Kitamoto, Tetsuyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006469/ https://www.ncbi.nlm.nih.gov/pubmed/36915552 http://dx.doi.org/10.1016/j.heliyon.2023.e13974

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