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Method validation of a bridging immunoassay in combination with acid-dissociation and bead treatment for detection of anti-drug antibody

Anti-drug antibody (ADA) positivity is correlated with disease relapse risk when treated with monoclonal antibody (mAb) therapeutics. ADA evaluation can assist with interpreting pharmacokinetic, pharmacological, and toxicology results. Here, we established an ADA assay based on two steps of acid dis...

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Detalles Bibliográficos
Autores principales:	Du, Jialiang, Yang, Yalan, Zhu, Lingling, Wang, Shaoyi, Yu, Chuanfei, Liu, Chunyu, Long, Caifeng, Chen, Baowen, Xu, Gangling, Zou, Linglong, Wang, Lan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006523/ https://www.ncbi.nlm.nih.gov/pubmed/36915535 http://dx.doi.org/10.1016/j.heliyon.2023.e13999

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