The EGFR C797S Mutation Confers Resistance to a Novel EGFR Inhibitor CLN-081 to EGFR Exon 20 Insertion Mutations

INTRODUCTION: EGFR exon 20 insertion mutations account for 5% to 10% of EGFR-mutated NSCLC. CLN-081 (formerly known as TAS6417), a novel covalent EGFR tyrosine kinase inhibitor, exhibits pan-mutation selective efficacy, including exon 20 insertions, in the clinical setting. Nevertheless, some patien...

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Detalles Bibliográficos
Autores principales: Kagawa, Yosuke, Hayashida, Takuma, Liu, Jie, Mori, Shunta, Izumi, Hiroki, Kumagai, Shogo, Udagawa, Hibiki, Hattori, Noboru, Goto, Koichi, Kobayashi, Susumu S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006853/
https://www.ncbi.nlm.nih.gov/pubmed/36915628
http://dx.doi.org/10.1016/j.jtocrr.2023.100462

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