Cargando…

Abnormal Brain Circuits Characterize Borderline Personality and Mediate the Relationship between Childhood Traumas and Symptoms: A mCCA+jICA and Random Forest Approach

Borderline personality disorder (BPD) is a severe personality disorder whose neural bases are still unclear. Indeed, previous studies reported inconsistent findings concerning alterations in cortical and subcortical areas. In the present study, we applied for the first time a combination of an unsup...

Descripción completa

Detalles Bibliográficos
Autores principales: Grecucci, Alessandro, Dadomo, Harold, Salvato, Gerardo, Lapomarda, Gaia, Sorella, Sara, Messina, Irene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006907/
https://www.ncbi.nlm.nih.gov/pubmed/36905064
http://dx.doi.org/10.3390/s23052862
_version_ 1784905387032444928
author Grecucci, Alessandro
Dadomo, Harold
Salvato, Gerardo
Lapomarda, Gaia
Sorella, Sara
Messina, Irene
author_facet Grecucci, Alessandro
Dadomo, Harold
Salvato, Gerardo
Lapomarda, Gaia
Sorella, Sara
Messina, Irene
author_sort Grecucci, Alessandro
collection PubMed
description Borderline personality disorder (BPD) is a severe personality disorder whose neural bases are still unclear. Indeed, previous studies reported inconsistent findings concerning alterations in cortical and subcortical areas. In the present study, we applied for the first time a combination of an unsupervised machine learning approach known as multimodal canonical correlation analysis plus joint independent component analysis (mCCA+jICA), in combination with a supervised machine learning approach known as random forest, to possibly find covarying gray matter and white matter (GM-WM) circuits that separate BPD from controls and that are also predictive of this diagnosis. The first analysis was used to decompose the brain into independent circuits of covarying grey and white matter concentrations. The second method was used to develop a predictive model able to correctly classify new unobserved BPD cases based on one or more circuits derived from the first analysis. To this aim, we analyzed the structural images of patients with BPD and matched healthy controls (HCs). The results showed that two GM-WM covarying circuits, including basal ganglia, amygdala, and portions of the temporal lobes and of the orbitofrontal cortex, correctly classified BPD against HC. Notably, these circuits are affected by specific child traumatic experiences (emotional and physical neglect, and physical abuse) and predict symptoms severity in the interpersonal and impulsivity domains. These results support that BPD is characterized by anomalies in both GM and WM circuits related to early traumatic experiences and specific symptoms.
format Online
Article
Text
id pubmed-10006907
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100069072023-03-12 Abnormal Brain Circuits Characterize Borderline Personality and Mediate the Relationship between Childhood Traumas and Symptoms: A mCCA+jICA and Random Forest Approach Grecucci, Alessandro Dadomo, Harold Salvato, Gerardo Lapomarda, Gaia Sorella, Sara Messina, Irene Sensors (Basel) Article Borderline personality disorder (BPD) is a severe personality disorder whose neural bases are still unclear. Indeed, previous studies reported inconsistent findings concerning alterations in cortical and subcortical areas. In the present study, we applied for the first time a combination of an unsupervised machine learning approach known as multimodal canonical correlation analysis plus joint independent component analysis (mCCA+jICA), in combination with a supervised machine learning approach known as random forest, to possibly find covarying gray matter and white matter (GM-WM) circuits that separate BPD from controls and that are also predictive of this diagnosis. The first analysis was used to decompose the brain into independent circuits of covarying grey and white matter concentrations. The second method was used to develop a predictive model able to correctly classify new unobserved BPD cases based on one or more circuits derived from the first analysis. To this aim, we analyzed the structural images of patients with BPD and matched healthy controls (HCs). The results showed that two GM-WM covarying circuits, including basal ganglia, amygdala, and portions of the temporal lobes and of the orbitofrontal cortex, correctly classified BPD against HC. Notably, these circuits are affected by specific child traumatic experiences (emotional and physical neglect, and physical abuse) and predict symptoms severity in the interpersonal and impulsivity domains. These results support that BPD is characterized by anomalies in both GM and WM circuits related to early traumatic experiences and specific symptoms. MDPI 2023-03-06 /pmc/articles/PMC10006907/ /pubmed/36905064 http://dx.doi.org/10.3390/s23052862 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Grecucci, Alessandro
Dadomo, Harold
Salvato, Gerardo
Lapomarda, Gaia
Sorella, Sara
Messina, Irene
Abnormal Brain Circuits Characterize Borderline Personality and Mediate the Relationship between Childhood Traumas and Symptoms: A mCCA+jICA and Random Forest Approach
title Abnormal Brain Circuits Characterize Borderline Personality and Mediate the Relationship between Childhood Traumas and Symptoms: A mCCA+jICA and Random Forest Approach
title_full Abnormal Brain Circuits Characterize Borderline Personality and Mediate the Relationship between Childhood Traumas and Symptoms: A mCCA+jICA and Random Forest Approach
title_fullStr Abnormal Brain Circuits Characterize Borderline Personality and Mediate the Relationship between Childhood Traumas and Symptoms: A mCCA+jICA and Random Forest Approach
title_full_unstemmed Abnormal Brain Circuits Characterize Borderline Personality and Mediate the Relationship between Childhood Traumas and Symptoms: A mCCA+jICA and Random Forest Approach
title_short Abnormal Brain Circuits Characterize Borderline Personality and Mediate the Relationship between Childhood Traumas and Symptoms: A mCCA+jICA and Random Forest Approach
title_sort abnormal brain circuits characterize borderline personality and mediate the relationship between childhood traumas and symptoms: a mcca+jica and random forest approach
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006907/
https://www.ncbi.nlm.nih.gov/pubmed/36905064
http://dx.doi.org/10.3390/s23052862
work_keys_str_mv AT grecuccialessandro abnormalbraincircuitscharacterizeborderlinepersonalityandmediatetherelationshipbetweenchildhoodtraumasandsymptomsamccajicaandrandomforestapproach
AT dadomoharold abnormalbraincircuitscharacterizeborderlinepersonalityandmediatetherelationshipbetweenchildhoodtraumasandsymptomsamccajicaandrandomforestapproach
AT salvatogerardo abnormalbraincircuitscharacterizeborderlinepersonalityandmediatetherelationshipbetweenchildhoodtraumasandsymptomsamccajicaandrandomforestapproach
AT lapomardagaia abnormalbraincircuitscharacterizeborderlinepersonalityandmediatetherelationshipbetweenchildhoodtraumasandsymptomsamccajicaandrandomforestapproach
AT sorellasara abnormalbraincircuitscharacterizeborderlinepersonalityandmediatetherelationshipbetweenchildhoodtraumasandsymptomsamccajicaandrandomforestapproach
AT messinairene abnormalbraincircuitscharacterizeborderlinepersonalityandmediatetherelationshipbetweenchildhoodtraumasandsymptomsamccajicaandrandomforestapproach