Cargando…

Optical Glucose Sensors Based on Chitosan-Capped ZnS-Doped Mn Nanomaterials

The primary goal of glucose sensing at the point of care is to identify glucose concentrations within the diabetes range. However, lower glucose levels also pose a severe health risk. In this paper, we propose quick, simple, and reliable glucose sensors based on the absorption and photoluminescence...

Descripción completa

Detalles Bibliográficos
Autores principales: Nguyen, Son Hai, Vu, Phan Kim Thi, Nguyen, Hung Manh, Tran, Mai Thi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006924/
https://www.ncbi.nlm.nih.gov/pubmed/36905045
http://dx.doi.org/10.3390/s23052841
_version_ 1784905391314829312
author Nguyen, Son Hai
Vu, Phan Kim Thi
Nguyen, Hung Manh
Tran, Mai Thi
author_facet Nguyen, Son Hai
Vu, Phan Kim Thi
Nguyen, Hung Manh
Tran, Mai Thi
author_sort Nguyen, Son Hai
collection PubMed
description The primary goal of glucose sensing at the point of care is to identify glucose concentrations within the diabetes range. However, lower glucose levels also pose a severe health risk. In this paper, we propose quick, simple, and reliable glucose sensors based on the absorption and photoluminescence spectra of chitosan-capped ZnS-doped Mn nanomaterials in the range of 0.125 to 0.636 mM glucose corresponding to 2.3 mg/dL to 11.4 mg/dL. The detection limit was 0.125 mM (or 2.3 mg/dL), much lower than the hypoglycemia level of 70 mg/dL (or 3.9 mM). Chitosan-capped ZnS-doped Mn nanomaterials retain their optical properties while improving sensor stability. This study reports for the first time how the sensors’ efficacy was affected by chitosan content from 0.75 to 1.5 wt.%. The results showed that 1 %wt chitosan-capped ZnS-doped Mn is the most-sensitive, -selective, and -stable material. We also put the biosensor through its paces with glucose in phosphate-buffered saline. In the same range of 0.125 to 0.636 mM, the sensors-based chitosan-coated ZnS-doped Mn had a better sensitivity than the working water environment.
format Online
Article
Text
id pubmed-10006924
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100069242023-03-12 Optical Glucose Sensors Based on Chitosan-Capped ZnS-Doped Mn Nanomaterials Nguyen, Son Hai Vu, Phan Kim Thi Nguyen, Hung Manh Tran, Mai Thi Sensors (Basel) Communication The primary goal of glucose sensing at the point of care is to identify glucose concentrations within the diabetes range. However, lower glucose levels also pose a severe health risk. In this paper, we propose quick, simple, and reliable glucose sensors based on the absorption and photoluminescence spectra of chitosan-capped ZnS-doped Mn nanomaterials in the range of 0.125 to 0.636 mM glucose corresponding to 2.3 mg/dL to 11.4 mg/dL. The detection limit was 0.125 mM (or 2.3 mg/dL), much lower than the hypoglycemia level of 70 mg/dL (or 3.9 mM). Chitosan-capped ZnS-doped Mn nanomaterials retain their optical properties while improving sensor stability. This study reports for the first time how the sensors’ efficacy was affected by chitosan content from 0.75 to 1.5 wt.%. The results showed that 1 %wt chitosan-capped ZnS-doped Mn is the most-sensitive, -selective, and -stable material. We also put the biosensor through its paces with glucose in phosphate-buffered saline. In the same range of 0.125 to 0.636 mM, the sensors-based chitosan-coated ZnS-doped Mn had a better sensitivity than the working water environment. MDPI 2023-03-06 /pmc/articles/PMC10006924/ /pubmed/36905045 http://dx.doi.org/10.3390/s23052841 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Nguyen, Son Hai
Vu, Phan Kim Thi
Nguyen, Hung Manh
Tran, Mai Thi
Optical Glucose Sensors Based on Chitosan-Capped ZnS-Doped Mn Nanomaterials
title Optical Glucose Sensors Based on Chitosan-Capped ZnS-Doped Mn Nanomaterials
title_full Optical Glucose Sensors Based on Chitosan-Capped ZnS-Doped Mn Nanomaterials
title_fullStr Optical Glucose Sensors Based on Chitosan-Capped ZnS-Doped Mn Nanomaterials
title_full_unstemmed Optical Glucose Sensors Based on Chitosan-Capped ZnS-Doped Mn Nanomaterials
title_short Optical Glucose Sensors Based on Chitosan-Capped ZnS-Doped Mn Nanomaterials
title_sort optical glucose sensors based on chitosan-capped zns-doped mn nanomaterials
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006924/
https://www.ncbi.nlm.nih.gov/pubmed/36905045
http://dx.doi.org/10.3390/s23052841
work_keys_str_mv AT nguyensonhai opticalglucosesensorsbasedonchitosancappedznsdopedmnnanomaterials
AT vuphankimthi opticalglucosesensorsbasedonchitosancappedznsdopedmnnanomaterials
AT nguyenhungmanh opticalglucosesensorsbasedonchitosancappedznsdopedmnnanomaterials
AT tranmaithi opticalglucosesensorsbasedonchitosancappedznsdopedmnnanomaterials