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Optical Glucose Sensors Based on Chitosan-Capped ZnS-Doped Mn Nanomaterials
The primary goal of glucose sensing at the point of care is to identify glucose concentrations within the diabetes range. However, lower glucose levels also pose a severe health risk. In this paper, we propose quick, simple, and reliable glucose sensors based on the absorption and photoluminescence...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006924/ https://www.ncbi.nlm.nih.gov/pubmed/36905045 http://dx.doi.org/10.3390/s23052841 |
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author | Nguyen, Son Hai Vu, Phan Kim Thi Nguyen, Hung Manh Tran, Mai Thi |
author_facet | Nguyen, Son Hai Vu, Phan Kim Thi Nguyen, Hung Manh Tran, Mai Thi |
author_sort | Nguyen, Son Hai |
collection | PubMed |
description | The primary goal of glucose sensing at the point of care is to identify glucose concentrations within the diabetes range. However, lower glucose levels also pose a severe health risk. In this paper, we propose quick, simple, and reliable glucose sensors based on the absorption and photoluminescence spectra of chitosan-capped ZnS-doped Mn nanomaterials in the range of 0.125 to 0.636 mM glucose corresponding to 2.3 mg/dL to 11.4 mg/dL. The detection limit was 0.125 mM (or 2.3 mg/dL), much lower than the hypoglycemia level of 70 mg/dL (or 3.9 mM). Chitosan-capped ZnS-doped Mn nanomaterials retain their optical properties while improving sensor stability. This study reports for the first time how the sensors’ efficacy was affected by chitosan content from 0.75 to 1.5 wt.%. The results showed that 1 %wt chitosan-capped ZnS-doped Mn is the most-sensitive, -selective, and -stable material. We also put the biosensor through its paces with glucose in phosphate-buffered saline. In the same range of 0.125 to 0.636 mM, the sensors-based chitosan-coated ZnS-doped Mn had a better sensitivity than the working water environment. |
format | Online Article Text |
id | pubmed-10006924 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100069242023-03-12 Optical Glucose Sensors Based on Chitosan-Capped ZnS-Doped Mn Nanomaterials Nguyen, Son Hai Vu, Phan Kim Thi Nguyen, Hung Manh Tran, Mai Thi Sensors (Basel) Communication The primary goal of glucose sensing at the point of care is to identify glucose concentrations within the diabetes range. However, lower glucose levels also pose a severe health risk. In this paper, we propose quick, simple, and reliable glucose sensors based on the absorption and photoluminescence spectra of chitosan-capped ZnS-doped Mn nanomaterials in the range of 0.125 to 0.636 mM glucose corresponding to 2.3 mg/dL to 11.4 mg/dL. The detection limit was 0.125 mM (or 2.3 mg/dL), much lower than the hypoglycemia level of 70 mg/dL (or 3.9 mM). Chitosan-capped ZnS-doped Mn nanomaterials retain their optical properties while improving sensor stability. This study reports for the first time how the sensors’ efficacy was affected by chitosan content from 0.75 to 1.5 wt.%. The results showed that 1 %wt chitosan-capped ZnS-doped Mn is the most-sensitive, -selective, and -stable material. We also put the biosensor through its paces with glucose in phosphate-buffered saline. In the same range of 0.125 to 0.636 mM, the sensors-based chitosan-coated ZnS-doped Mn had a better sensitivity than the working water environment. MDPI 2023-03-06 /pmc/articles/PMC10006924/ /pubmed/36905045 http://dx.doi.org/10.3390/s23052841 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Nguyen, Son Hai Vu, Phan Kim Thi Nguyen, Hung Manh Tran, Mai Thi Optical Glucose Sensors Based on Chitosan-Capped ZnS-Doped Mn Nanomaterials |
title | Optical Glucose Sensors Based on Chitosan-Capped ZnS-Doped Mn Nanomaterials |
title_full | Optical Glucose Sensors Based on Chitosan-Capped ZnS-Doped Mn Nanomaterials |
title_fullStr | Optical Glucose Sensors Based on Chitosan-Capped ZnS-Doped Mn Nanomaterials |
title_full_unstemmed | Optical Glucose Sensors Based on Chitosan-Capped ZnS-Doped Mn Nanomaterials |
title_short | Optical Glucose Sensors Based on Chitosan-Capped ZnS-Doped Mn Nanomaterials |
title_sort | optical glucose sensors based on chitosan-capped zns-doped mn nanomaterials |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006924/ https://www.ncbi.nlm.nih.gov/pubmed/36905045 http://dx.doi.org/10.3390/s23052841 |
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