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Optical Penetration of Shape-Controlled Metallic Nanosensors across Membrane Barriers

Precise nanostructure geometry that enables the optical biomolecular delivery of nanosensors to the living intracellular environment is highly desirable for precision biological and clinical therapies. However, the optical delivery through membrane barriers utilizing nanosensors remains difficult du...

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Detalles Bibliográficos
Autores principales: Da, Ancheng, Chu, Yanan, Krach, Jacob, Liu, Yunbo, Park, Younggeun, Lee, Somin Eunice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007193/
https://www.ncbi.nlm.nih.gov/pubmed/36905027
http://dx.doi.org/10.3390/s23052824
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author Da, Ancheng
Chu, Yanan
Krach, Jacob
Liu, Yunbo
Park, Younggeun
Lee, Somin Eunice
author_facet Da, Ancheng
Chu, Yanan
Krach, Jacob
Liu, Yunbo
Park, Younggeun
Lee, Somin Eunice
author_sort Da, Ancheng
collection PubMed
description Precise nanostructure geometry that enables the optical biomolecular delivery of nanosensors to the living intracellular environment is highly desirable for precision biological and clinical therapies. However, the optical delivery through membrane barriers utilizing nanosensors remains difficult due to a lack of design guidelines to avoid inherent conflict between optical force and photothermal heat generation in metallic nanosensors during the process. Here, we present a numerical study reporting significantly enhanced optical penetration of nanosensors by engineering nanostructure geometry with minimized photothermal heating generation for penetrating across membrane barriers. We show that by varying the nanosensor geometry, penetration depths can be maximized while heat generated during the penetration process can be minimized. We demonstrate the effect of lateral stress induced by an angularly rotating nanosensor on a membrane barrier by theoretical analysis. Furthermore, we show that by varying the nanosensor geometry, maximized local stress fields at the nanoparticle–membrane interface enhanced the optical penetration process by four-fold. Owing to the high efficiency and stability, we anticipate that precise optical penetration of nanosensors to specific intracellular locations will be beneficial for biological and therapeutic applications.
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spelling pubmed-100071932023-03-12 Optical Penetration of Shape-Controlled Metallic Nanosensors across Membrane Barriers Da, Ancheng Chu, Yanan Krach, Jacob Liu, Yunbo Park, Younggeun Lee, Somin Eunice Sensors (Basel) Article Precise nanostructure geometry that enables the optical biomolecular delivery of nanosensors to the living intracellular environment is highly desirable for precision biological and clinical therapies. However, the optical delivery through membrane barriers utilizing nanosensors remains difficult due to a lack of design guidelines to avoid inherent conflict between optical force and photothermal heat generation in metallic nanosensors during the process. Here, we present a numerical study reporting significantly enhanced optical penetration of nanosensors by engineering nanostructure geometry with minimized photothermal heating generation for penetrating across membrane barriers. We show that by varying the nanosensor geometry, penetration depths can be maximized while heat generated during the penetration process can be minimized. We demonstrate the effect of lateral stress induced by an angularly rotating nanosensor on a membrane barrier by theoretical analysis. Furthermore, we show that by varying the nanosensor geometry, maximized local stress fields at the nanoparticle–membrane interface enhanced the optical penetration process by four-fold. Owing to the high efficiency and stability, we anticipate that precise optical penetration of nanosensors to specific intracellular locations will be beneficial for biological and therapeutic applications. MDPI 2023-03-04 /pmc/articles/PMC10007193/ /pubmed/36905027 http://dx.doi.org/10.3390/s23052824 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Da, Ancheng
Chu, Yanan
Krach, Jacob
Liu, Yunbo
Park, Younggeun
Lee, Somin Eunice
Optical Penetration of Shape-Controlled Metallic Nanosensors across Membrane Barriers
title Optical Penetration of Shape-Controlled Metallic Nanosensors across Membrane Barriers
title_full Optical Penetration of Shape-Controlled Metallic Nanosensors across Membrane Barriers
title_fullStr Optical Penetration of Shape-Controlled Metallic Nanosensors across Membrane Barriers
title_full_unstemmed Optical Penetration of Shape-Controlled Metallic Nanosensors across Membrane Barriers
title_short Optical Penetration of Shape-Controlled Metallic Nanosensors across Membrane Barriers
title_sort optical penetration of shape-controlled metallic nanosensors across membrane barriers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007193/
https://www.ncbi.nlm.nih.gov/pubmed/36905027
http://dx.doi.org/10.3390/s23052824
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