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Quaternized Poly(N,N′-dimethylaminoethyl methacrylate) Star Nanostructures in the Solution and on the Surface

Antibacterial polymeric materials are promising in the fight against resistant bacteria strains. Amongst them, cationic macromolecules with quaternary ammonium groups are one of intensively studied, as they interact with the bacterial membranes causing cell death. In this work, we propose to use nan...

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Autores principales: Teper, Paulina, Celny, Anna, Kowalczuk, Agnieszka, Mendrek, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007306/
https://www.ncbi.nlm.nih.gov/pubmed/36904499
http://dx.doi.org/10.3390/polym15051260
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author Teper, Paulina
Celny, Anna
Kowalczuk, Agnieszka
Mendrek, Barbara
author_facet Teper, Paulina
Celny, Anna
Kowalczuk, Agnieszka
Mendrek, Barbara
author_sort Teper, Paulina
collection PubMed
description Antibacterial polymeric materials are promising in the fight against resistant bacteria strains. Amongst them, cationic macromolecules with quaternary ammonium groups are one of intensively studied, as they interact with the bacterial membranes causing cell death. In this work, we propose to use nanostructures composed of polycations with star topology for the preparation of antibacterial materials. First, star polymers of N,N′-dimethylaminoethyl methacrylate and hydroxyl-bearing oligo(ethylene glycol) methacrylate P(DMAEMA-co-OEGMA-OH) were quaternized with various bromoalkanes and their solution behavior was studied. It was shown that in water two modes of star nanoparticles were observed, of diameters about 30 nm and up to 125 nm, independently of the quaternizing agent. Separately layers of P(DMAEMA-co-OEGMA-OH) stars were obtained. In this case, the chemical grafting of polymers to the silicon wafers modified with imidazole derivatives was applied, followed by the quaternization of the amino groups of polycations. A comparison of the quaternary reaction in solution and on the surface showed that in the solution it is influenced by the alkyl chain length of the quaternary agent, while on the surface such relationship is not observed. After physico-chemical characterization of the obtained nanolayers, their biocidal activity was tested against two strains of bacteria E. coli and B. subtilis. The best antibacterial properties exhibited layers quaternized with shorter alkyl bromide, where 100% growth inhibition of E. coli and B. subtilis after 24 h of contact was observed.
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spelling pubmed-100073062023-03-12 Quaternized Poly(N,N′-dimethylaminoethyl methacrylate) Star Nanostructures in the Solution and on the Surface Teper, Paulina Celny, Anna Kowalczuk, Agnieszka Mendrek, Barbara Polymers (Basel) Article Antibacterial polymeric materials are promising in the fight against resistant bacteria strains. Amongst them, cationic macromolecules with quaternary ammonium groups are one of intensively studied, as they interact with the bacterial membranes causing cell death. In this work, we propose to use nanostructures composed of polycations with star topology for the preparation of antibacterial materials. First, star polymers of N,N′-dimethylaminoethyl methacrylate and hydroxyl-bearing oligo(ethylene glycol) methacrylate P(DMAEMA-co-OEGMA-OH) were quaternized with various bromoalkanes and their solution behavior was studied. It was shown that in water two modes of star nanoparticles were observed, of diameters about 30 nm and up to 125 nm, independently of the quaternizing agent. Separately layers of P(DMAEMA-co-OEGMA-OH) stars were obtained. In this case, the chemical grafting of polymers to the silicon wafers modified with imidazole derivatives was applied, followed by the quaternization of the amino groups of polycations. A comparison of the quaternary reaction in solution and on the surface showed that in the solution it is influenced by the alkyl chain length of the quaternary agent, while on the surface such relationship is not observed. After physico-chemical characterization of the obtained nanolayers, their biocidal activity was tested against two strains of bacteria E. coli and B. subtilis. The best antibacterial properties exhibited layers quaternized with shorter alkyl bromide, where 100% growth inhibition of E. coli and B. subtilis after 24 h of contact was observed. MDPI 2023-03-01 /pmc/articles/PMC10007306/ /pubmed/36904499 http://dx.doi.org/10.3390/polym15051260 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Teper, Paulina
Celny, Anna
Kowalczuk, Agnieszka
Mendrek, Barbara
Quaternized Poly(N,N′-dimethylaminoethyl methacrylate) Star Nanostructures in the Solution and on the Surface
title Quaternized Poly(N,N′-dimethylaminoethyl methacrylate) Star Nanostructures in the Solution and on the Surface
title_full Quaternized Poly(N,N′-dimethylaminoethyl methacrylate) Star Nanostructures in the Solution and on the Surface
title_fullStr Quaternized Poly(N,N′-dimethylaminoethyl methacrylate) Star Nanostructures in the Solution and on the Surface
title_full_unstemmed Quaternized Poly(N,N′-dimethylaminoethyl methacrylate) Star Nanostructures in the Solution and on the Surface
title_short Quaternized Poly(N,N′-dimethylaminoethyl methacrylate) Star Nanostructures in the Solution and on the Surface
title_sort quaternized poly(n,n′-dimethylaminoethyl methacrylate) star nanostructures in the solution and on the surface
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007306/
https://www.ncbi.nlm.nih.gov/pubmed/36904499
http://dx.doi.org/10.3390/polym15051260
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