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Mechanisms of Foreign Body Giant Cell Formation in Response to Implantable Biomaterials
Long term function of implantable biomaterials are determined by their integration with the host’s body. Immune reactions against these implants could impair the function and integration of the implants. Some biomaterial-based implants lead to macrophage fusion and the formation of multinucleated gi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007405/ https://www.ncbi.nlm.nih.gov/pubmed/36904554 http://dx.doi.org/10.3390/polym15051313 |
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author | Eslami-Kaliji, Farshid Hedayat Nia, Niloufar Lakey, Jonathan R. T. Smink, Alexandra M. Mohammadi, Mohammadreza |
author_facet | Eslami-Kaliji, Farshid Hedayat Nia, Niloufar Lakey, Jonathan R. T. Smink, Alexandra M. Mohammadi, Mohammadreza |
author_sort | Eslami-Kaliji, Farshid |
collection | PubMed |
description | Long term function of implantable biomaterials are determined by their integration with the host’s body. Immune reactions against these implants could impair the function and integration of the implants. Some biomaterial-based implants lead to macrophage fusion and the formation of multinucleated giant cells, also known as foreign body giant cells (FBGCs). FBGCs may compromise the biomaterial performance and may lead to implant rejection and adverse events in some cases. Despite their critical role in response to implants, there is a limited understanding of cellular and molecular mechanisms involved in forming FBGCs. Here, we focused on better understanding the steps and mechanisms triggering macrophage fusion and FBGCs formation, specifically in response to biomaterials. These steps included macrophage adhesion to the biomaterial surface, fusion competency, mechanosensing and mechanotransduction-mediated migration, and the final fusion. We also described some of the key biomarkers and biomolecules involved in these steps. Understanding these steps on a molecular level would lead to enhance biomaterials design and improve their function in the context of cell transplantation, tissue engineering, and drug delivery. |
format | Online Article Text |
id | pubmed-10007405 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100074052023-03-12 Mechanisms of Foreign Body Giant Cell Formation in Response to Implantable Biomaterials Eslami-Kaliji, Farshid Hedayat Nia, Niloufar Lakey, Jonathan R. T. Smink, Alexandra M. Mohammadi, Mohammadreza Polymers (Basel) Review Long term function of implantable biomaterials are determined by their integration with the host’s body. Immune reactions against these implants could impair the function and integration of the implants. Some biomaterial-based implants lead to macrophage fusion and the formation of multinucleated giant cells, also known as foreign body giant cells (FBGCs). FBGCs may compromise the biomaterial performance and may lead to implant rejection and adverse events in some cases. Despite their critical role in response to implants, there is a limited understanding of cellular and molecular mechanisms involved in forming FBGCs. Here, we focused on better understanding the steps and mechanisms triggering macrophage fusion and FBGCs formation, specifically in response to biomaterials. These steps included macrophage adhesion to the biomaterial surface, fusion competency, mechanosensing and mechanotransduction-mediated migration, and the final fusion. We also described some of the key biomarkers and biomolecules involved in these steps. Understanding these steps on a molecular level would lead to enhance biomaterials design and improve their function in the context of cell transplantation, tissue engineering, and drug delivery. MDPI 2023-03-06 /pmc/articles/PMC10007405/ /pubmed/36904554 http://dx.doi.org/10.3390/polym15051313 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Eslami-Kaliji, Farshid Hedayat Nia, Niloufar Lakey, Jonathan R. T. Smink, Alexandra M. Mohammadi, Mohammadreza Mechanisms of Foreign Body Giant Cell Formation in Response to Implantable Biomaterials |
title | Mechanisms of Foreign Body Giant Cell Formation in Response to Implantable Biomaterials |
title_full | Mechanisms of Foreign Body Giant Cell Formation in Response to Implantable Biomaterials |
title_fullStr | Mechanisms of Foreign Body Giant Cell Formation in Response to Implantable Biomaterials |
title_full_unstemmed | Mechanisms of Foreign Body Giant Cell Formation in Response to Implantable Biomaterials |
title_short | Mechanisms of Foreign Body Giant Cell Formation in Response to Implantable Biomaterials |
title_sort | mechanisms of foreign body giant cell formation in response to implantable biomaterials |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007405/ https://www.ncbi.nlm.nih.gov/pubmed/36904554 http://dx.doi.org/10.3390/polym15051313 |
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