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Methods and Characteristics of Drug Extraction from Ion-Exchange-Resin-Mediated Preparations: Influences, Thermodynamics, and Kinetics

Since the discovery of ion-exchange resins, they have been used in many fields, including pharmacy. Ion-exchange resin-mediated preparations can realize a series of functions, such as taste masking and regulating release. However, it is very difficult to extract the drug completely from the drug–res...

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Autores principales: Yuan, Junlin, Li, Conghui, Wang, Shanshan, Zhang, Hui, Wang, Zengming, Zheng, Aiping, Gao, Xiuli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007538/
https://www.ncbi.nlm.nih.gov/pubmed/36904432
http://dx.doi.org/10.3390/polym15051191
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author Yuan, Junlin
Li, Conghui
Wang, Shanshan
Zhang, Hui
Wang, Zengming
Zheng, Aiping
Gao, Xiuli
author_facet Yuan, Junlin
Li, Conghui
Wang, Shanshan
Zhang, Hui
Wang, Zengming
Zheng, Aiping
Gao, Xiuli
author_sort Yuan, Junlin
collection PubMed
description Since the discovery of ion-exchange resins, they have been used in many fields, including pharmacy. Ion-exchange resin-mediated preparations can realize a series of functions, such as taste masking and regulating release. However, it is very difficult to extract the drug completely from the drug–resin complex because of the specific combination of the drug and resin. In this study, methylphenidate hydrochloride extended-release chewable tablets compounded by methylphenidate hydrochloride and ion-exchange resin were selected for a drug extraction study. The efficiency of drug extraction by dissociating with the addition of counterions was found to be higher than other physical extraction methods. Then, the factors affecting the dissociation process were studied to completely extract the drug from the methylphenidate hydrochloride extended-release chewable tablets. Furthermore, the thermodynamic and kinetic study of the dissociation process showed that the dissociation process obeys the second-order kinetic process, and it is nonspontaneous, entropy-decreasing, and endothermic. Meanwhile, the reaction rate was confirmed by the Boyd model, and the film diffusion and matrix diffusion were both shown to be rate-limiting steps. In conclusion, this study aims to provide technological and theoretical support for establishing a quality assessment and control system of ion-exchange resin-mediated preparations, promoting the applications of ion-exchange resins in the field of drug preparation.
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spelling pubmed-100075382023-03-12 Methods and Characteristics of Drug Extraction from Ion-Exchange-Resin-Mediated Preparations: Influences, Thermodynamics, and Kinetics Yuan, Junlin Li, Conghui Wang, Shanshan Zhang, Hui Wang, Zengming Zheng, Aiping Gao, Xiuli Polymers (Basel) Article Since the discovery of ion-exchange resins, they have been used in many fields, including pharmacy. Ion-exchange resin-mediated preparations can realize a series of functions, such as taste masking and regulating release. However, it is very difficult to extract the drug completely from the drug–resin complex because of the specific combination of the drug and resin. In this study, methylphenidate hydrochloride extended-release chewable tablets compounded by methylphenidate hydrochloride and ion-exchange resin were selected for a drug extraction study. The efficiency of drug extraction by dissociating with the addition of counterions was found to be higher than other physical extraction methods. Then, the factors affecting the dissociation process were studied to completely extract the drug from the methylphenidate hydrochloride extended-release chewable tablets. Furthermore, the thermodynamic and kinetic study of the dissociation process showed that the dissociation process obeys the second-order kinetic process, and it is nonspontaneous, entropy-decreasing, and endothermic. Meanwhile, the reaction rate was confirmed by the Boyd model, and the film diffusion and matrix diffusion were both shown to be rate-limiting steps. In conclusion, this study aims to provide technological and theoretical support for establishing a quality assessment and control system of ion-exchange resin-mediated preparations, promoting the applications of ion-exchange resins in the field of drug preparation. MDPI 2023-02-27 /pmc/articles/PMC10007538/ /pubmed/36904432 http://dx.doi.org/10.3390/polym15051191 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yuan, Junlin
Li, Conghui
Wang, Shanshan
Zhang, Hui
Wang, Zengming
Zheng, Aiping
Gao, Xiuli
Methods and Characteristics of Drug Extraction from Ion-Exchange-Resin-Mediated Preparations: Influences, Thermodynamics, and Kinetics
title Methods and Characteristics of Drug Extraction from Ion-Exchange-Resin-Mediated Preparations: Influences, Thermodynamics, and Kinetics
title_full Methods and Characteristics of Drug Extraction from Ion-Exchange-Resin-Mediated Preparations: Influences, Thermodynamics, and Kinetics
title_fullStr Methods and Characteristics of Drug Extraction from Ion-Exchange-Resin-Mediated Preparations: Influences, Thermodynamics, and Kinetics
title_full_unstemmed Methods and Characteristics of Drug Extraction from Ion-Exchange-Resin-Mediated Preparations: Influences, Thermodynamics, and Kinetics
title_short Methods and Characteristics of Drug Extraction from Ion-Exchange-Resin-Mediated Preparations: Influences, Thermodynamics, and Kinetics
title_sort methods and characteristics of drug extraction from ion-exchange-resin-mediated preparations: influences, thermodynamics, and kinetics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007538/
https://www.ncbi.nlm.nih.gov/pubmed/36904432
http://dx.doi.org/10.3390/polym15051191
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