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Association of Heart Rate Variability with Pulmonary Function Impairment and Symptomatology Post-COVID-19 Hospitalization
The persistence of symptoms beyond three months after COVID-19 infection, often referred to as post-COVID-19 condition (PCC), is commonly experienced. It is hypothesized that PCC results from autonomic dysfunction with decreased vagal nerve activity, which can be indexed by low heart rate variabilit...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007596/ https://www.ncbi.nlm.nih.gov/pubmed/36904676 http://dx.doi.org/10.3390/s23052473 |
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author | Adang, Estelle A. M. C. Strous, Maud T. A. van den Bergh, Joop P. Gach, Debbie van Kampen, Vivian E. M. van Zeeland, Roel E. P. Barten, Dennis G. van Osch, Frits H. M. |
author_facet | Adang, Estelle A. M. C. Strous, Maud T. A. van den Bergh, Joop P. Gach, Debbie van Kampen, Vivian E. M. van Zeeland, Roel E. P. Barten, Dennis G. van Osch, Frits H. M. |
author_sort | Adang, Estelle A. M. C. |
collection | PubMed |
description | The persistence of symptoms beyond three months after COVID-19 infection, often referred to as post-COVID-19 condition (PCC), is commonly experienced. It is hypothesized that PCC results from autonomic dysfunction with decreased vagal nerve activity, which can be indexed by low heart rate variability (HRV). The aim of this study was to assess the association of HRV upon admission with pulmonary function impairment and the number of reported symptoms beyond three months after initial hospitalization for COVID-19 between February and December 2020. Follow-up took place three to five months after discharge and included pulmonary function tests and the assessment of persistent symptoms. HRV analysis was performed on one 10 s electrocardiogram obtained upon admission. Analyses were performed using multivariable and multinomial logistic regression models. Among 171 patients who received follow-up, and with an electrocardiogram at admission, decreased diffusion capacity of the lung for carbon monoxide (DLCO) (41%) was most frequently found. After a median of 119 days (IQR 101–141), 81% of the participants reported at least one symptom. HRV was not associated with pulmonary function impairment or persistent symptoms three to five months after hospitalization for COVID-19. |
format | Online Article Text |
id | pubmed-10007596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100075962023-03-12 Association of Heart Rate Variability with Pulmonary Function Impairment and Symptomatology Post-COVID-19 Hospitalization Adang, Estelle A. M. C. Strous, Maud T. A. van den Bergh, Joop P. Gach, Debbie van Kampen, Vivian E. M. van Zeeland, Roel E. P. Barten, Dennis G. van Osch, Frits H. M. Sensors (Basel) Article The persistence of symptoms beyond three months after COVID-19 infection, often referred to as post-COVID-19 condition (PCC), is commonly experienced. It is hypothesized that PCC results from autonomic dysfunction with decreased vagal nerve activity, which can be indexed by low heart rate variability (HRV). The aim of this study was to assess the association of HRV upon admission with pulmonary function impairment and the number of reported symptoms beyond three months after initial hospitalization for COVID-19 between February and December 2020. Follow-up took place three to five months after discharge and included pulmonary function tests and the assessment of persistent symptoms. HRV analysis was performed on one 10 s electrocardiogram obtained upon admission. Analyses were performed using multivariable and multinomial logistic regression models. Among 171 patients who received follow-up, and with an electrocardiogram at admission, decreased diffusion capacity of the lung for carbon monoxide (DLCO) (41%) was most frequently found. After a median of 119 days (IQR 101–141), 81% of the participants reported at least one symptom. HRV was not associated with pulmonary function impairment or persistent symptoms three to five months after hospitalization for COVID-19. MDPI 2023-02-23 /pmc/articles/PMC10007596/ /pubmed/36904676 http://dx.doi.org/10.3390/s23052473 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Adang, Estelle A. M. C. Strous, Maud T. A. van den Bergh, Joop P. Gach, Debbie van Kampen, Vivian E. M. van Zeeland, Roel E. P. Barten, Dennis G. van Osch, Frits H. M. Association of Heart Rate Variability with Pulmonary Function Impairment and Symptomatology Post-COVID-19 Hospitalization |
title | Association of Heart Rate Variability with Pulmonary Function Impairment and Symptomatology Post-COVID-19 Hospitalization |
title_full | Association of Heart Rate Variability with Pulmonary Function Impairment and Symptomatology Post-COVID-19 Hospitalization |
title_fullStr | Association of Heart Rate Variability with Pulmonary Function Impairment and Symptomatology Post-COVID-19 Hospitalization |
title_full_unstemmed | Association of Heart Rate Variability with Pulmonary Function Impairment and Symptomatology Post-COVID-19 Hospitalization |
title_short | Association of Heart Rate Variability with Pulmonary Function Impairment and Symptomatology Post-COVID-19 Hospitalization |
title_sort | association of heart rate variability with pulmonary function impairment and symptomatology post-covid-19 hospitalization |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007596/ https://www.ncbi.nlm.nih.gov/pubmed/36904676 http://dx.doi.org/10.3390/s23052473 |
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