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RNA demethylase ALKBH5 promotes tumorigenesis of t (8;21) acute myeloid leukemia via ITPA m6A modification

BACKGROUND: Although t (8;21) is in fact considered a good risk acute myeloid leukemia (AML), only 60% of the patients live beyond 5 years after diagnosis. Studies have shown that RNA demethylase ALKBH5 promotes leukemogenesis. However, the molecular mechanism and clinical significance of ALKBH5 in...

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Detalles Bibliográficos
Autores principales:	Li, Ran, Wu, Xiaolu, Xue, Kai, Feng, Dandan, Li, Jianyong, Li, Junmin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007764/ https://www.ncbi.nlm.nih.gov/pubmed/36899424 http://dx.doi.org/10.1186/s40364-023-00464-x

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