[(18)F]F-DED PET imaging of reactive astrogliosis in neurodegenerative diseases: preclinical proof of concept and first-in-human data

OBJECTIVES: Reactive gliosis is a common pathological hallmark of CNS pathology resulting from neurodegeneration and neuroinflammation. In this study we investigate the capability of a novel monoamine oxidase B (MAO-B) PET ligand to monitor reactive astrogliosis in a transgenic mouse model of Alzhei...

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Detalles Bibliográficos
Autores principales: Ballweg, Anna, Klaus, Carolin, Vogler, Letizia, Katzdobler, Sabrina, Wind, Karin, Zatcepin, Artem, Ziegler, Sibylle I., Secgin, Birkan, Eckenweber, Florian, Bohr, Bernd, Bernhardt, Alexander, Fietzek, Urban, Rauchmann, Boris-Stephan, Stoecklein, Sophia, Quach, Stefanie, Beyer, Leonie, Scheifele, Maximilian, Simmet, Marcel, Joseph, Emanuel, Lindner, Simon, Berg, Isabella, Koglin, Norman, Mueller, Andre, Stephens, Andrew W., Bartenstein, Peter, Tonn, Joerg C., Albert, Nathalie L., Kümpfel, Tania, Kerschensteiner, Martin, Perneczky, Robert, Levin, Johannes, Paeger, Lars, Herms, Jochen, Brendel, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007845/
https://www.ncbi.nlm.nih.gov/pubmed/36906584
http://dx.doi.org/10.1186/s12974-023-02749-2

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