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Implications of serum uric acid for female infertility: results from the national health and nutrition examination survey, 2013–2020

BACKGROUND: There is limited concrete evidence connecting serum uric acid levels to female infertility. Therefore, this study aimed to find out if serum uric acid levels are independently related to female infertility. METHODS: From the National Health and Nutrition Examination Survey (NHANES) 2013–...

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Autores principales: Liang, Jiemei, Chen, Xiting, Huang, Jinfa, Nie, Weizhe, Yang, Qian, Huang, Qitao, Deng, Kaixian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007853/
https://www.ncbi.nlm.nih.gov/pubmed/36906587
http://dx.doi.org/10.1186/s12905-023-02234-1
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author Liang, Jiemei
Chen, Xiting
Huang, Jinfa
Nie, Weizhe
Yang, Qian
Huang, Qitao
Deng, Kaixian
author_facet Liang, Jiemei
Chen, Xiting
Huang, Jinfa
Nie, Weizhe
Yang, Qian
Huang, Qitao
Deng, Kaixian
author_sort Liang, Jiemei
collection PubMed
description BACKGROUND: There is limited concrete evidence connecting serum uric acid levels to female infertility. Therefore, this study aimed to find out if serum uric acid levels are independently related to female infertility. METHODS: From the National Health and Nutrition Examination Survey (NHANES) 2013–2020, a total sample of 5872 chosen female participants between the ages of 18 and 49 were identified for this cross-sectional study. The serum uric acid levels (mg/dL) of each participant were tested, and the reproductive health questionnaire was used to evaluate each subject's reproductive status. Both in the analyses of the full sample and each subgroup, logistic regression models were used to evaluate the relationship between the two variables. A stratified multivariate logistic regression model was used to perform the subgroup analysis based on serum uric acid levels. RESULTS: Infertility was found in 649 (11.1%) of the 5,872 female adults in this study, with greater mean serum uric acid levels (4.7 mg/dL vs. 4.5 mg/dL). Serum uric acid levels were associated with infertility in both the initial and adjusted models. According to multivariate logistic regression, the odds of female infertility were found to be significantly higher with rising serum uric acid levels (Q4 [≥ 5.2 mg/dL] vs. Q1 [≤ 3.6 mg/dL]), adjusted odds ratio [aOR] = 1.59, p = 0.002]. The data suggests that there is a dose–response relationship between the two. CONCLUSIONS: The results from this nationally representative sample from the United States confirmed the idea that there is a link between increased serum uric acid levels and female infertility. Future research is necessary to evaluate the relationship between serum uric acid levels and female infertility and explicate the underlying mechanisms of this relationship.
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spelling pubmed-100078532023-03-12 Implications of serum uric acid for female infertility: results from the national health and nutrition examination survey, 2013–2020 Liang, Jiemei Chen, Xiting Huang, Jinfa Nie, Weizhe Yang, Qian Huang, Qitao Deng, Kaixian BMC Womens Health Research BACKGROUND: There is limited concrete evidence connecting serum uric acid levels to female infertility. Therefore, this study aimed to find out if serum uric acid levels are independently related to female infertility. METHODS: From the National Health and Nutrition Examination Survey (NHANES) 2013–2020, a total sample of 5872 chosen female participants between the ages of 18 and 49 were identified for this cross-sectional study. The serum uric acid levels (mg/dL) of each participant were tested, and the reproductive health questionnaire was used to evaluate each subject's reproductive status. Both in the analyses of the full sample and each subgroup, logistic regression models were used to evaluate the relationship between the two variables. A stratified multivariate logistic regression model was used to perform the subgroup analysis based on serum uric acid levels. RESULTS: Infertility was found in 649 (11.1%) of the 5,872 female adults in this study, with greater mean serum uric acid levels (4.7 mg/dL vs. 4.5 mg/dL). Serum uric acid levels were associated with infertility in both the initial and adjusted models. According to multivariate logistic regression, the odds of female infertility were found to be significantly higher with rising serum uric acid levels (Q4 [≥ 5.2 mg/dL] vs. Q1 [≤ 3.6 mg/dL]), adjusted odds ratio [aOR] = 1.59, p = 0.002]. The data suggests that there is a dose–response relationship between the two. CONCLUSIONS: The results from this nationally representative sample from the United States confirmed the idea that there is a link between increased serum uric acid levels and female infertility. Future research is necessary to evaluate the relationship between serum uric acid levels and female infertility and explicate the underlying mechanisms of this relationship. BioMed Central 2023-03-11 /pmc/articles/PMC10007853/ /pubmed/36906587 http://dx.doi.org/10.1186/s12905-023-02234-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Liang, Jiemei
Chen, Xiting
Huang, Jinfa
Nie, Weizhe
Yang, Qian
Huang, Qitao
Deng, Kaixian
Implications of serum uric acid for female infertility: results from the national health and nutrition examination survey, 2013–2020
title Implications of serum uric acid for female infertility: results from the national health and nutrition examination survey, 2013–2020
title_full Implications of serum uric acid for female infertility: results from the national health and nutrition examination survey, 2013–2020
title_fullStr Implications of serum uric acid for female infertility: results from the national health and nutrition examination survey, 2013–2020
title_full_unstemmed Implications of serum uric acid for female infertility: results from the national health and nutrition examination survey, 2013–2020
title_short Implications of serum uric acid for female infertility: results from the national health and nutrition examination survey, 2013–2020
title_sort implications of serum uric acid for female infertility: results from the national health and nutrition examination survey, 2013–2020
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007853/
https://www.ncbi.nlm.nih.gov/pubmed/36906587
http://dx.doi.org/10.1186/s12905-023-02234-1
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