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Biological effects of prostaglandin E2-EP4 antagonist (AAT-008) in murine colon cancer in vivo: enhancement of immune response to radiotherapy and potential as a radiosensitizer

BACKGROUND: Prostaglandin E2 (PGE2) promotes tumor growth and metastasis by acting on a family of four receptors (EP1–4). We investigated the radiosensitizing effects of a newly developed antagonist of PGE2-EP4 (AAT-008) in mouse colon cancer cells in vivo and explored the mechanism using flow cytom...

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Detalles Bibliográficos
Autores principales:	Manabe, Yoshihiko, Takahashi, Yutaka, Sugie, Chikao, Wang, Zhen, Katsuki, Shohei, Kondo, Takuhito, Murai, Taro, Nakashima, Masahiro, Takaoka, Taiki, Ogawa, Kazuhiko, Shibamoto, Yuta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007874/ https://www.ncbi.nlm.nih.gov/pubmed/36915594 http://dx.doi.org/10.21037/tcr-22-1857

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