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Leukoencephalopathy in children with acute lymphoblastic leukemia after chemotherapy: a retrospective monocenter study
BACKGROUND: To investigate the clinical and neuroimaging characteristics of leukoencephalopathy among children with acute lymphoblastic leukemia (ALL), especially after chemotherapy. METHODS: Clinical data for 17 pediatric patients with leukoencephalopathy and 17 matched controls were retrospectivel...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007887/ https://www.ncbi.nlm.nih.gov/pubmed/36915585 http://dx.doi.org/10.21037/tcr-22-2180 |
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author | Xiao, Xiao Chu, Si-Jia Tang, Ji-Hong Zhang, Li-Ya Zhang, Bing-Bing |
author_facet | Xiao, Xiao Chu, Si-Jia Tang, Ji-Hong Zhang, Li-Ya Zhang, Bing-Bing |
author_sort | Xiao, Xiao |
collection | PubMed |
description | BACKGROUND: To investigate the clinical and neuroimaging characteristics of leukoencephalopathy among children with acute lymphoblastic leukemia (ALL), especially after chemotherapy. METHODS: Clinical data for 17 pediatric patients with leukoencephalopathy and 17 matched controls were retrospectively analyzed. All participants were children with ALL admitted to the Children’s Hospital of Soochow University from May 2011 to April 2021. The data mainly consisted of general information, laboratory studies, and imaging diagnostic results. RESULTS: Overall, 94.12% of the patients experienced neurological symptoms. The most common symptoms were seizure (7/17, 41.18%), nausea (5/17, 29.41%), vomiting (5/17, 29.41%), paralysis (5/17, 29.41%), and numbness (4/17, 23.53%). On neuroimaging, multiple and irregular lesions were observed, distributed mainly in the periventricular area (9/17, 52.94%), parietal lobe (6/17, 35.29%), and basal ganglia (5/17, 29.41%). Moreover, there were significant differences in serum sodium (P=0.0001), C-reactive protein (P=0.0124) and blood pressure (P=0.0271) between patients with and without leukoencephalopathy. After aggressive treatment, the clinical symptoms (12/17, 70.59%) and imaging lesions (11/13, 84.62%) gradually improved in most patients. CONCLUSIONS: Chemotherapy is an important risk factor related to leukoencephalopathy. Although the clinical symptoms of leukoencephalopathy vary widely, there is a high degree of consistency in its radiological features. Abnormal laboratory results may also help the identification of leukoencephalopathy. Early detection and treatment can improve brain development in the long term. |
format | Online Article Text |
id | pubmed-10007887 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-100078872023-03-12 Leukoencephalopathy in children with acute lymphoblastic leukemia after chemotherapy: a retrospective monocenter study Xiao, Xiao Chu, Si-Jia Tang, Ji-Hong Zhang, Li-Ya Zhang, Bing-Bing Transl Cancer Res Original Article BACKGROUND: To investigate the clinical and neuroimaging characteristics of leukoencephalopathy among children with acute lymphoblastic leukemia (ALL), especially after chemotherapy. METHODS: Clinical data for 17 pediatric patients with leukoencephalopathy and 17 matched controls were retrospectively analyzed. All participants were children with ALL admitted to the Children’s Hospital of Soochow University from May 2011 to April 2021. The data mainly consisted of general information, laboratory studies, and imaging diagnostic results. RESULTS: Overall, 94.12% of the patients experienced neurological symptoms. The most common symptoms were seizure (7/17, 41.18%), nausea (5/17, 29.41%), vomiting (5/17, 29.41%), paralysis (5/17, 29.41%), and numbness (4/17, 23.53%). On neuroimaging, multiple and irregular lesions were observed, distributed mainly in the periventricular area (9/17, 52.94%), parietal lobe (6/17, 35.29%), and basal ganglia (5/17, 29.41%). Moreover, there were significant differences in serum sodium (P=0.0001), C-reactive protein (P=0.0124) and blood pressure (P=0.0271) between patients with and without leukoencephalopathy. After aggressive treatment, the clinical symptoms (12/17, 70.59%) and imaging lesions (11/13, 84.62%) gradually improved in most patients. CONCLUSIONS: Chemotherapy is an important risk factor related to leukoencephalopathy. Although the clinical symptoms of leukoencephalopathy vary widely, there is a high degree of consistency in its radiological features. Abnormal laboratory results may also help the identification of leukoencephalopathy. Early detection and treatment can improve brain development in the long term. AME Publishing Company 2023-01-06 2023-02-28 /pmc/articles/PMC10007887/ /pubmed/36915585 http://dx.doi.org/10.21037/tcr-22-2180 Text en 2023 Translational Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Original Article Xiao, Xiao Chu, Si-Jia Tang, Ji-Hong Zhang, Li-Ya Zhang, Bing-Bing Leukoencephalopathy in children with acute lymphoblastic leukemia after chemotherapy: a retrospective monocenter study |
title | Leukoencephalopathy in children with acute lymphoblastic leukemia after chemotherapy: a retrospective monocenter study |
title_full | Leukoencephalopathy in children with acute lymphoblastic leukemia after chemotherapy: a retrospective monocenter study |
title_fullStr | Leukoencephalopathy in children with acute lymphoblastic leukemia after chemotherapy: a retrospective monocenter study |
title_full_unstemmed | Leukoencephalopathy in children with acute lymphoblastic leukemia after chemotherapy: a retrospective monocenter study |
title_short | Leukoencephalopathy in children with acute lymphoblastic leukemia after chemotherapy: a retrospective monocenter study |
title_sort | leukoencephalopathy in children with acute lymphoblastic leukemia after chemotherapy: a retrospective monocenter study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007887/ https://www.ncbi.nlm.nih.gov/pubmed/36915585 http://dx.doi.org/10.21037/tcr-22-2180 |
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