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SIRT1 Inhibits High Glucose–Induced TXNIP/NLRP3 Inflammasome Activation and Cataract Formation

PURPOSE: To determine whether SIRT1 regulates high glucose (HG)–induced inflammation and cataract formation through modulating TXNIP/NLRP3 inflammasome activation in human lens epithelial cells (HLECs) and rat lenses. METHODS: HG stress from 25 to 150 mM was imposed on HLECs, with treatments using s...

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Detalles Bibliográficos
Autores principales:	Lian, Lili, Le, Zhenmin, Wang, Zhenzhen, Chen, Ying-ao, Jiao, Xiaodong, Qi, Hang, Hejtmancik, J. Fielding, Ma, Xiaoyin, Zheng, Qinxiang, Ren, Yueping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2023
Materias:	Lens
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007902/ https://www.ncbi.nlm.nih.gov/pubmed/36881408 http://dx.doi.org/10.1167/iovs.64.3.16

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