Targeting Caspase-3 Gene in rCHO Cell Line by CRISPR/Cas9 Editing Tool and Its Effect on Protein Production in Manipulated Cell Line

BACKGROUND: Chinese hamster ovary (CHO) cells are the widely used mammalian cell host for biopharmaceutical manufacturing. During cell cultures, CHO cells lose viability mainly from apoptosis. Inhibiting cell death is useful because prolonging cell lifespans can direct to more productive cell cultur...

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Detalles Bibliográficos
Autores principales: Rahimi, Amirabbas, Karimipoor, Morteza, Mahdian, Reza, Alipour, Atefeh, Hosseini, Sadi, Kaghazian, Hooman, Abbasi, Abdolrahim, Shahsavarani, Hosein, Shokrgozar, Mohammad Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Brieflands 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007989/
https://www.ncbi.nlm.nih.gov/pubmed/36915405
http://dx.doi.org/10.5812/ijpr-130236

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