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Characterization of in-vivo human metabolites of the oral nucleoside anti-COVID-19 drug VV116 using UHPLC-Orbitrap-MS

VV116 is an oral nucleoside anti-COVID-19 drug undergoing clinical trials in China. We aimed to characterize its metabolites in plasma, urine, and feces of healthy Chinese male subjects after a single oral administration of 400 mg VV116, by using UHPLC-UV-Orbitrap-MS. After oral administration, VV11...

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Detalles Bibliográficos
Autores principales:	Zhou, Ainan, Wang, Zhen, Diao, Xingxing, Zhong, Dafang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier B.V. 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008097/ https://www.ncbi.nlm.nih.gov/pubmed/36924632 http://dx.doi.org/10.1016/j.jpba.2023.115340

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