Effect of Moderate Intensity Continuous Training and Slow Type Interval Training to Gene Expression of TGF-β in Type 2 Diabetes Mellitus Model Wistar Rats

BACKGROUND: Physical exercise is a process of increasing contraction of skeletal muscles involving several organ systems to increase energy formation and it is one of the pillars for the management of type 2 diabetes mellitus (TDM2). T2DM affects the expression of the TGF-β gene. OBJECTIVE: This study aims to determine the effect of moderate intensity continuous training and slow interval training in expression of TGF-β gene in wistar rats T2DM model. METHODS: A moderate intensity continuous training physical activity given to the diabetic rat group in the form of running on a treadmill with a running speed of 20 m/min for 30 minutes while the slow type interval training physical activity given to the diabetic rat group was in the form of running on a treadmill with a running speed of 20 m/minute for 10 repetition sessions, with a duration of 2 minutes per session with interspersed active breaks for 1 minute. TGF-β gene expression was measured using real-time methods. RESULTS: The results in the continuous group, TGF-β significant decreased p < 0.05. In the interval group, TGF- β insignificant decreased p > 0.05. Moderate intensity continuous training was insignificantly better at decreasing the expression of the TGF-β genes. CONCLUSION: This research concluded that there is an effect of moderate intensity continuous training and slow interval training on the expression of TGF-β genes in wistar rats T2DM.