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Prediction of Surgical Treatment in Acute Pancreatitis Using Biochemical and Clinical Parameters
BACKGROUND: Deep Acute pancreatitis (AP) is an urging cause of hospitalization in the gastroenterology due to different causes and an unpredictable outcome. Known causes are grouped into four main groups: metabolic, mechanical, vascular and infectious. OBJECTIVE: To determine the role of certain bio...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Academy of Medical Sciences of Bosnia and Herzegovina
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008264/ https://www.ncbi.nlm.nih.gov/pubmed/36919134 http://dx.doi.org/10.5455/medarh.2023.77.29-33 |
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author | Husic - Selimovic, Azra Bijedic, Nina Sofic, Amela Selimagic, Amir Vanis, Nedim Jahic, Rijad Kapetanovic, Sanja |
author_facet | Husic - Selimovic, Azra Bijedic, Nina Sofic, Amela Selimagic, Amir Vanis, Nedim Jahic, Rijad Kapetanovic, Sanja |
author_sort | Husic - Selimovic, Azra |
collection | PubMed |
description | BACKGROUND: Deep Acute pancreatitis (AP) is an urging cause of hospitalization in the gastroenterology due to different causes and an unpredictable outcome. Known causes are grouped into four main groups: metabolic, mechanical, vascular and infectious. OBJECTIVE: To determine the role of certain biochemical or radiological parameters as predictors of an involvement of other organs in AP different pathological staging and the surgical outcome in the treatment of AP. METHODS: Ninety-seven AP patients hospitalized in General Hospital “Prim.dr Abdulah Nakaš” Sarajevo, in a period between 2016 and 2021 for both sexes, were divided according to the etiological factors of AP into four groups: nutritional factors, biliary concernments, alcohol and morphological changes of the pancreas. Beside laboratory tests, the imaging methods of abdomen (transabdominal ultrasound, abdominal computed tomography) used in determining morphological changes in the pancreas and other organs were analyzed in relation to parameters that predict the need for surgical outcomes. RESULTS: AP etiological factors of patients differ significantly by gender and showed the dominance of dietary factors in female subjects (51%), followed by the presence of concernments in the biliary tract in 36% of cases, and alcohol consumption in male subjects in 28% of cases. The only variable correlated with the indicator of necessity for surgery is the existence of pleural effusion (coefficient of correlation was 0.38; risk ratio was 5.5) resulting that patients with pleural effusion have a 5.5 times higher chance of surgery indication than other patients. CONCLUSION: The application of simple parameters such as creatinine value with the values of amylases in serum and urine and the presence of pleural effusion confirmed by radiological imaging of the lungs opens the possibility of a simple and effective selection of patients for surgical treatment with a more severe form of AP. |
format | Online Article Text |
id | pubmed-10008264 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Academy of Medical Sciences of Bosnia and Herzegovina |
record_format | MEDLINE/PubMed |
spelling | pubmed-100082642023-03-13 Prediction of Surgical Treatment in Acute Pancreatitis Using Biochemical and Clinical Parameters Husic - Selimovic, Azra Bijedic, Nina Sofic, Amela Selimagic, Amir Vanis, Nedim Jahic, Rijad Kapetanovic, Sanja Med Arch Original Paper BACKGROUND: Deep Acute pancreatitis (AP) is an urging cause of hospitalization in the gastroenterology due to different causes and an unpredictable outcome. Known causes are grouped into four main groups: metabolic, mechanical, vascular and infectious. OBJECTIVE: To determine the role of certain biochemical or radiological parameters as predictors of an involvement of other organs in AP different pathological staging and the surgical outcome in the treatment of AP. METHODS: Ninety-seven AP patients hospitalized in General Hospital “Prim.dr Abdulah Nakaš” Sarajevo, in a period between 2016 and 2021 for both sexes, were divided according to the etiological factors of AP into four groups: nutritional factors, biliary concernments, alcohol and morphological changes of the pancreas. Beside laboratory tests, the imaging methods of abdomen (transabdominal ultrasound, abdominal computed tomography) used in determining morphological changes in the pancreas and other organs were analyzed in relation to parameters that predict the need for surgical outcomes. RESULTS: AP etiological factors of patients differ significantly by gender and showed the dominance of dietary factors in female subjects (51%), followed by the presence of concernments in the biliary tract in 36% of cases, and alcohol consumption in male subjects in 28% of cases. The only variable correlated with the indicator of necessity for surgery is the existence of pleural effusion (coefficient of correlation was 0.38; risk ratio was 5.5) resulting that patients with pleural effusion have a 5.5 times higher chance of surgery indication than other patients. CONCLUSION: The application of simple parameters such as creatinine value with the values of amylases in serum and urine and the presence of pleural effusion confirmed by radiological imaging of the lungs opens the possibility of a simple and effective selection of patients for surgical treatment with a more severe form of AP. Academy of Medical Sciences of Bosnia and Herzegovina 2023-02 /pmc/articles/PMC10008264/ /pubmed/36919134 http://dx.doi.org/10.5455/medarh.2023.77.29-33 Text en © 2023 Azra Husic - Selimovic, Nina Bijedic, Amela Sofic, Amir Selimagic, Nedim Vanis, Rijad Jahic, Sanja Kapetanovic https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Paper Husic - Selimovic, Azra Bijedic, Nina Sofic, Amela Selimagic, Amir Vanis, Nedim Jahic, Rijad Kapetanovic, Sanja Prediction of Surgical Treatment in Acute Pancreatitis Using Biochemical and Clinical Parameters |
title | Prediction of Surgical Treatment in Acute Pancreatitis Using Biochemical and Clinical Parameters |
title_full | Prediction of Surgical Treatment in Acute Pancreatitis Using Biochemical and Clinical Parameters |
title_fullStr | Prediction of Surgical Treatment in Acute Pancreatitis Using Biochemical and Clinical Parameters |
title_full_unstemmed | Prediction of Surgical Treatment in Acute Pancreatitis Using Biochemical and Clinical Parameters |
title_short | Prediction of Surgical Treatment in Acute Pancreatitis Using Biochemical and Clinical Parameters |
title_sort | prediction of surgical treatment in acute pancreatitis using biochemical and clinical parameters |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008264/ https://www.ncbi.nlm.nih.gov/pubmed/36919134 http://dx.doi.org/10.5455/medarh.2023.77.29-33 |
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