Cellular senescence: when growth stimulation meets cell cycle arrest

At the very moment of cell-cycle arrest, the cell is not senescent yet. For several days in cell culture, the arrested cell is acquiring a senescent phenotype. What is happening during this geroconversion? Cellular enlargement (hypertrophy) and hyperfunctions (lysosomal and hyper-secretory) are hall...

Descripción completa

Detalles Bibliográficos
Autor principal: Blagosklonny, Mikhail V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008486/
https://www.ncbi.nlm.nih.gov/pubmed/36805938
http://dx.doi.org/10.18632/aging.204543
_version_ 1784905768271609856
author Blagosklonny, Mikhail V.
author_facet Blagosklonny, Mikhail V.
author_sort Blagosklonny, Mikhail V.
collection PubMed
description At the very moment of cell-cycle arrest, the cell is not senescent yet. For several days in cell culture, the arrested cell is acquiring a senescent phenotype. What is happening during this geroconversion? Cellular enlargement (hypertrophy) and hyperfunctions (lysosomal and hyper-secretory) are hallmarks of geroconversion.
format Online
Article
Text
id pubmed-10008486
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Impact Journals
record_format MEDLINE/PubMed
spelling pubmed-100084862023-03-13 Cellular senescence: when growth stimulation meets cell cycle arrest Blagosklonny, Mikhail V. Aging (Albany NY) Review At the very moment of cell-cycle arrest, the cell is not senescent yet. For several days in cell culture, the arrested cell is acquiring a senescent phenotype. What is happening during this geroconversion? Cellular enlargement (hypertrophy) and hyperfunctions (lysosomal and hyper-secretory) are hallmarks of geroconversion. Impact Journals 2023-02-19 /pmc/articles/PMC10008486/ /pubmed/36805938 http://dx.doi.org/10.18632/aging.204543 Text en Copyright: © 2023 Blagosklonny https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Blagosklonny, Mikhail V.
Cellular senescence: when growth stimulation meets cell cycle arrest
title Cellular senescence: when growth stimulation meets cell cycle arrest
title_full Cellular senescence: when growth stimulation meets cell cycle arrest
title_fullStr Cellular senescence: when growth stimulation meets cell cycle arrest
title_full_unstemmed Cellular senescence: when growth stimulation meets cell cycle arrest
title_short Cellular senescence: when growth stimulation meets cell cycle arrest
title_sort cellular senescence: when growth stimulation meets cell cycle arrest
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008486/
https://www.ncbi.nlm.nih.gov/pubmed/36805938
http://dx.doi.org/10.18632/aging.204543
work_keys_str_mv AT blagosklonnymikhailv cellularsenescencewhengrowthstimulationmeetscellcyclearrest

Ejemplares similares